Effects of Ca2+ channel blockers on store-operated Ca2+ channel currents of Kupffer cells after hepatic ischemia/reperfusion injury in rats

Table 1 Effects of 2-APB on Isoc at the test potential of -100 mV (mean ± SD, n = 8)

Group (μmol/L)	Peak current (pA)	t	Inhibitive rate (%)
Control	-227.8 ± 68.5
2-APB (20)	-139.6 ± 52.9b	7.6	39.0 ± 10.3
2-APB (40)	-109.6 ± 36.4b	6.2	50.8 ± 12.2
2-APB (60)	-88.1 ± 37.6b	6.7	61.0 ± 15.1
2-APB (80)	-72.4 ± 37.1b	6.8	67.7 ± 15.1
2-APB (100)	-57.8 ± 33.4b	6.9	73.7 ± 14.3

^bP < 0.01 vs control.

Table 2 Effects of SK&F96365 on Isoc at the test potential of -100 mV (mean ± SD, n = 11)

Group (μmol/L)	Peak current (pA)	t	Inhibitive rate (%)
Control	-161.7 ± 58.7
SK&F96365 (5)	-82.6 ± 29.5b	5.3	46.1 ± 17.3
SK&F96365 (10)	-57.0 ± 24.9b	6.1	61.2 ± 20.5
SK&F96365 (20)	-47.1 ± 20.5b	6.5	67.2 ± 19.5
SK&F96365 (40)	-35.6 ± 15.4b	7.1	74.8 ± 15.2
SK&F96365 (50)	-25.3 ± 11.9b	7.7	82.1 ± 11.0

^bP < 0.01 vs control.

Table 3 Effects of econazole on Isoc at the test potential of -100 mV (mean ± SD, n = 13)

Group (μmol/L)	Peak current (pA)	t	Inhibitive rate (%)
Control	-147.2 ± 35.7
econazole (0.1)	-83.5 ± 22.8b	6.7	42.0 ± 15.1
econazole (0.3)	-64.7 ± 18.9b	8.7	54.6 ± 14.7
econazole (1)	-56.6 ± 19.9b	9.8	60.7 ± 13.7
econazole (3)	-47.9 ± 18.2b	10.3	66.5 ± 13.5
econazole (10)	-39.9 ± 15.9b	11.1	71.9 ± 12.6

^bP < 0.01 vs control.

Table 4 Effects of miconazole on Isoc at the test potential of -100 mV (mean ± SD, n = 10)

Group (μmol/L)	Peak current (pA)	t	Inhibitive rate (%)
Control	-133.2 ± 32.0
miconazole (0.1)	-86.4 ± 31.7b	7.1	35.6 ± 14.9
miconazole (0.3)	-63.8 ± 23.4b	10.7	52.3 ± 10.0
miconazole (1)	-45.9 ± 13.1b	9.2	64.5 ± 10.6
miconazole (3)	-36.8 ± 11.4b	9.9	71.3 ± 10.2
miconazole (10)	-29.7 ± 10.5b	9.9	76.5 ± 9.4

^bP < 0.01 vs control.