A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population

Table 1 Genotypic and allelic CD209 frequencies in celiac patients (n = 103) and controls (n = 312) from the Granada area

Genotype	Celiac patients	Controls	P
	n (%)	n (%)
AA	61 (59)	191 (61)
AG	36 (35)	109 (35)
GG	6 (6)	12 (4)	0.7
Allele
A	158 (77)	491 (78)
G	48 (23)	133 (21)	0.6

Table 2 Genotypic frequencies in HLA-DQ2 (+) and HLA-DQ (-) patients from the Granada area

Genotype	DQ2 (-) patients	DQ2 (+) patients
	(n = 7)	(n = 96)
AA	2	59
AG	5	31
GG	0	6

Table 3 Genotypic CD209 frequencies in DQ2 (-) (n = 29) and DQ2 (+) (n = 357) celiac patients and controls (n = 419) from the Madrid area

Genotype	DQ2 (-) patients	DQ2 (+) patients	Controls
	n (%)	n (%)	n (%)
AA	18 (62)	207 (58)	255 (61)
AG	6 (21)	131 (37)	142 (34)
GG	5 (17)	19 (5)	22 (5)

3*2 contingency table DQ2- vs DQ2+: P = 0.017; 3*2 contingency table DQ2- vs controls: P = 0.019; carriers A vs GG DQ2 (-) vs DQ2 (+): P = 0.026 OR = 3.71 (1.10-11.78); carriers A vs GG DQ2 (-) vs controls: P = 0.023 OR= 3.76 (1.14-11.73).