Is leptin related to systemic inflammatory response in acute pancreatitis?

Table 1 Body mass index (BMI) and leptin levels in acute pancreatitis (AP) according to severity status and gender

	n	BMI	BMI≥25	BMI≥30	Leptin (ng/mL)
		mean ± SD	n (%)	n (%)	Median (range)
All patients	52	27 ± 5	32 (63)	13 (25)	8.6 (0.5-215)
Severe AP	14	27 ± 5	7 (54)	2 (15)	10.3 (0.5-61)
Mild AP	38	27 ± 5	25 (66)	11 (29)	7.7 (0.5-215)
Women	29	27 ± 5	18 (64)	9 (32)	11 (0.5-215)a
Men	23	27 ± 4	14 (61)	4 (17)	3.7 (0.5-32)
Women & severe AP	7	24 ± 3b	2 (33)	0	10.4 (1.39 - 61)
Women & mild AP	22	28 ± 6	16 (73)	9 (41)	11.7 (0.5-215)
Men & severe AP	7	29 ± 6c	5 (71)	2 (29)	7 (0.5-32)d
Men & mild AP	16	26 ± 3	9 (65)	2 (13)	3.4 (0.5-19)

^aP = 0.008,

^bP = 0.04,

^cP = 0.05,

^dP = 0.1 (Mann-Whitney U-test).

Table 2 Independent association between leptin levels and severity of acute pancreatitis (AP) adjusted by gender and body mass index (BMI)

	Overall	Gender adjusted	BMI adjusted
Leptin and AP severity	P = 0.766	P = 0.5	P = 0.272

Table 3 Levels of cytokines (other than leptin) in acute pancreatitis (AP) according to severity status and gender

	All patients				Women			Men
	All patients	Severe AP	Mild AP	P	Severe AP	Mild AP	P	Severe AP	Mild AP	P
1TNF-α	0 (0-579)	13 (0-385)	0 (0-579)	0.021	30 (0-385)	0 (0-121)	0.036	2 (0-89)	1 (0-579)	NS
1IL-6	52 (1-560)	206 (10-590)	40 (1-537)	< 0.001	131 (10-361)	40 (1-180)	0.013	298 (195-590)	42 (3-537)	< 0.001
1IL-8	4 (0-4596)	99 (0-4596)	4 (0-1322)	NS	4 (0-780)	4 (0-496)	NS	182 (0-4596)	4 (0-1322)	NS
1IL-10	4 (0-560)	6 (0-54)	2 (0-560)	0.028	4 (0-17)	0 (0-49)	NS	27 (4-54)	4 (0-560)	NS

¹ pg/mL, all results expressed as median (range).

Table 4 Leptin correlation with other cytokines according to gender

		TNF-α	IL-6	IL-8	IL-10
		r (P)	r (P)	r (P)	r (P)
Leptin	All patients	NS	NS	0.265 (0.058)	NS
	Females	NS	NS	0.488 (0.007)	NS
	Males	0.487 (0.019)	0.397 (0.061)	NS	NS