Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats

Table 1 Effect of EGb on liver function in rats with CCl₄-induced injuries (mean ± SD)

Group	n	ALT (nkat•L-1)	AST (nkat•L-1)	Alb (g•L-1)
Control	10	42.8 ± 12.5	112.5 ± 36.5	35.3 ± 3.8
CCl4 treated	11	286.9 ± 52.6b	250.4 ± 22.5b	25.5 ± 4.8b
Colchicines	12	165.2 ± 36.5d	193.6 ± 20.8	29.5 ± 4.1
EGb	12	92.5 ± 27.5d	118.2 ± 18.2d	32.3 ± 6.2d

^bP < 0.01 vs control group;

^dP < 0.01 vs CCl₄-treated group.

Table 2 Effect of EGb on liver antioxidation in rats with CCl₄-induced injuries (mean ± SD)

Group	n	SOD (nkat•mg-1)	GSH-Px(nkat•g protein-1)	MDA (nmol•g-1)
Control	10	336.9 ± 82.4	482.4 ± 119.3	62.5 ± 15.6
CCl4 treated	11	51.5 ± 12.8b	162.5 ± 46.8b	323.5 ± 122.1b
Colchicines	12	112.5 ± 67.5d	178.2 ± 78.5d	168.3 ± 66.4d
EGb	12	165.2 ± 76.1d	303.6 ± 101.8a	112.3 ± 33.9a

^bP < 0.01 vs control group;

^dP < 0.01,

^aP < 0.05 vs CCl₄-treated group.

Table 3 Effect of EGb on serum levels of HA, PCIII and CIV (mean ± SD)

Group	n	HA (μg•L-1)	PCIII (μg•L-1)	CIV (μg•L-1)
Control	10	40.5 ± 7.8	15.3 ± 3.2	18.5 ± 4.0
CCl4 treated	11	126.9 ± 12.8a	36.5 ± 7.2a	56.2 ± 7.8b
Colchicines	12	79.2 ± 16.5b	23.5 ± 5.6b	33.6 ± 5.5d
EGb	12	91.5 ± 11.6b	28.5 ± 6.0a	38.4 ± 5.8a

^bP < 0.01 vs control group;

^dP < 0.01,

^aP < 0.05 vs CCl₄-treated group.

Table 4 Effect of EGb on degree of liver fibrosis in rats (mean ± SD)

Group	n	Degree of liver fibrosis
		0	I	II	III
Control	10	10	0	0	0
CCL4 treatedb	11	0	1	2	8
EGba	12	0	6	4	2

^bP < 0.01 vs control group;

^aP < 0.05 vs CCl₄-treated group.