Influence of a microscopic positive proximal margin in the treatment of gastric adenocarcinoma of the cardia

Table 1 Comparison of demographic and pathologic data between patients with positive and negative margins n (%)

Variable	Positive margins (n = 16)	Negative margins (n = 175)	P value
Age (years)	49.3 ± 12.7	57.5 ± 11.2	0.006
Sex			0.161
Male	8 (50.0)	121 (69.1)
Female	8 (50.0)	54 (30.9)
Siewert type			0.141
Type II	5 (31.3)	25 (14.3)
Type III	11 (68.7)	150 (85.7)
Gross type			0.001
Borrmann I, II	1 (6.3)	83 (47.4)
Borrmann III, IV	15 (93.7)	92 (52.6)
Tumor size (cm)			0.001
≤ 5 cm	2 (12.5)	98 (56.0)
> 5 cm	14 (87.5)	77 (44.0)
Histology			0.399
Differentiated	3 (18.8)	56 (32.0)
Undifferentiated	13 (81.2)	119 (68.0)
LRM (cm)			0.985
≤2	4 (25)	42 (24.0)
> 2 and ≤ 4	10 (62.5)	113 (64.6)
> 4	2 (12.5)	20 (11.4)

LRM: length of resection margin. Age represents mean ± SD.

Table 2 Comparison of tumor, node, metastasis classification, stage between patients with positive and negative margins n (%)

Variable	Positive margins (n = 16)	Negative margins (n = 175)	P value
Depth of tumor invasion			< 0.001
T1	0 (0)	29 (16.6)
T2	2 (12.5)	84 (48.0)
T3	11 (68.7)	55 (31.4)
T4	3 (18.8)	7 (4.0)
Node involvement			< 0.001
N0	3 (18.8)	67 (38.3)
N1	2 (12.5)	60 (34.3)
N2	2 (12.5)	26 (14.8)
N3	9 (56.2)	22 (12.6)
Stage			< 0.001
I	0 (0)	57 (32.6)
II	1 (6.3)	42 (24.0)
III	6 (37.5)	51 (29.1)
IV	9 (56.2)	25 (14.3)

Table 3 Logistic regression analysis of risk factors for a positive margin

Variable	Regression coefficient	Standard error	Odds ratio	95% CI for odds ratio	P value
Serosal invasion	2.300	0.782	9.970	2.152 - 46.196	0.003
Tumor size	1.875	0.787	6.524	1.395 - 30.512	0.017

Table 4 Multivariate analysis of prognostic factors for survival

Variable	Regression coefficient	Standard error	Odds ratio	95% CI for odds ratio	P value
Gross type	-0.174	0.258	0.840	0.507 - 1.392	0.500
Tumor size	0.209	0.248	1.232	0.758 - 2.001	0.399
Serosal invasion	-0.125	0.264	0.883	0.526 - 1.481	0.637
Node involvement	0.838	0.431	2.311	0.994 - 5.374	0.052
Stage	1.469	0.389	4.344	2.028 - 9.304	< 0.001
Margin status	0.397	0.330	1.488	0.779 - 2.843	0.229
Splenectomy	0.276	0.292	1.318	0.744 - 2.337	0.344