Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus

Table 1 Tumour characteristics

Parameter	CRP < 5.0 mg/dL	CRP ≥ 5.0 mg/dL	P-value
	(n = 127)	(n = 164)
Histologic type (n = 289)
-squamous cell carcinoma	56 (44%)	89 (55%)
-adenocarcinoma	62 (49%)	60 (37%)	0.150
-undifferentiated	6 (5%)	12 (7%)
-other	3 (2%)	1 (1%)
Location (n = 288)
-upper third	9 (7%)	15 (9%)
-middle third	42 (33%)	49 (30%)	0.748
-lower third	76 (60%)	97 (60%)
Tumour size (cm) (n = 281)	3 (0.5-12)	4.7 (0.7-20)	0.0001
Lymph nodes (n = 285)
-dissected	23.5 (0-71)	27 (2-86)	0.015
-positive	1 (0-24)	2 (0-41)	0.015
pT-category (n = 287)
-pT1	25 (20%)	19 (12%)
-pT2	34 (27%)	31 (19%)	0.055
-pT3	61 (49%)	98 (60%)
-pT4	5 (4%)	14 (9%)
pN-category (n = 286)
-pN0	54 (43%)	52 (32%)
-pN1	69 (56%)	107 (66%)	0.062
-pN2	1 (1%)	3 (2%)
pM-category (n = 283)
-pM0	96 (78%)	116 (73%)	0.177
-pM1	27 (22%)	44 (28%)

Table 2 Perioperative course

Parameter	CRP < 5.0 mg/dL	CRP ≥ 5.0 mg/dL	P-value
	(n = 127)	(n = 164)
Blood transfusion (n)
(n = 276)	0 (0-22)	1.5 (0-38)	0.006
ICU stay (d)
(n = 276)	9.5 (2-107)	11 (1-115)	0.094
Internal complications (n = 288)
	34 (27%)	74 (45%)	0.002
Surgical complications (n = 280)	46 (36%)	66 (41%)	0.469
-anastomotic leakage	22 (18%)	34 (21%)	0.549
-transplant necrosis	3 (3%)	7 (4%)	0.522
-mediastinitis	2 (2%)	3 (2%)	0.999
30-d-mortality
(n = 286)	9 (7%)	12 (7%)	0.999
Hospital mortality
(n = 280)	14 (11%)	21 (13%)	0.719

Table 3 Independent prognostic factors in 253 patients with oesophageal resection for carcinoma

Variable	95% confidence interval (CI)			P-value
	Hazard ratio	Lower border	Upper border
pT-category1				< 0.0001
-pT2	2.316	1.158	4.629	0.0174
-pT3	4.240	2.211	8.131	< 0.0001
-pT4	4.432	1.854	10.596	0.0008
R-classification2				0.0113
0	1.992	1.231	3.224	0.0050
-R2 and R2	-0.618	0.190	2.008	0.4234
CRP (logarithm)	1.182	1.030	1.356	0.0172
Surgical approach3				0.0345
-transthoracic	0.680	0.486	0.953	0.0249
-transhiatal	0.326	0.079	1.338	0.1196

¹ Reference category: pT0;

² Reference category: R0;

³ Reference category: transhiatal.