Drug treatment of functional dyspepsia

Table 1 Drug therapies used in the therapy of functional dyspepsia

Acid suppression therapy
Proton pump inhibitors1
	Omeprazole
	Lansoprazole
H2 blockers
	Cimetidine
	Ranitidine
	Famotidine
Simethicone
Herbal therapies
	Iberogast (Iberis, peppermint, Camomille)
	Artichoque leaf extract
	Xinwei decoction
	Ganaton (itorpide hydrochloride)
	Capsaicin
Motility agents
	Cisapride
	Domperidone
	Mosapride
	Erythromicin
H pylori eradication
Antidepressants
Serotonin reuptake inhibitors (SSRI)
Amitryptiline

¹Other PPI such as esomeprazole, rabeprazole and pantoprzole are also used to treat functional dyspepsia, but the largest and most significant trials reported to date have used either omeprazole or lansoprazole.

Table 2 Role of H pylori eradication in functional dyspepsia

Author	Name of study(if any)	Year	Type of study	No pts	Follow-up(mo)	Response
Mc Coll		1998	Singlecenter	218	12	Yes
Blum	OCAY	1998	Multicenter	438	12	No
Talley	ORCHID	1999	Multicenter	278	12	No
Talley		1999	Multicenter	170	12	No
Malfertheiner	ELAN	2001	Multicenter	180	12	Yes
Koelz	FROSCH	2003	Multicenter	181	6	No

Table 3 Role of acid suppression using PPI in functional dyspepsia

Author	Name of study	Year	Type of study	PPI	No pts	Follow-up	Response
Bolling-Sternevald	PILOT	1996	Multicenter	Omeprazole vs placebo	197	2 wk	Yes
Jones		1997	Multicenter	Lanzoprazole vs ranitidine	432	4 wk	L better than R
Talley	BOND	1998	Multicenter	Omeprazole vs placebo	642	4 wk	Yes
Talley	OPERA	1998	Multicenter	Omeprazole vs placebo	606	4 wk	No
Meineche-Schmidt	ENCORE	1999	Multicenter	Omeprazole vs placebo	567	3 mo	Yes
Peura		2004	Singlecenter	Lanzoprazole vs placebo	921	8 wk	Yes
Veldhuyzen	CADET-HN	2005	Multicenter	Omeprazole (O), ranitidine (R),cisapride(C), placebo	512	4 wk	O better than R, C or placebo