Three-dimensional conformal radiotherapy combined with FOLFOX4 chemotherapy for unresectable recurrent rectal cancer

Table 1 Clinical and pathologic characteristics of the patients

Variables	Control group(n = 25)	Study group(n = 23)
Age (yr): Median (range)	62 (36-70)	62 (40-72)
Sex
Male	17	14
Female	8	9
Dukes’ stage of initial lesion
A	1	1
B	7	5
C	17	17
Tumor pathologic type
Well and moderately differentiated adenocarcinoma	19	17
Mucinous adenocarcinoma	4	3
Signet ring cell carcinoma	2	3
Recurrent sites
Presacral	23	21
Pelvic sidewall	2	2

No significant differences in clinical or pathologic variables between the two groups were observed.

Table 2 WHO scale for acute toxicities

Toxicity	Grade	Control group	Study group	χ2value
Leukopenia	I	6	10
	II	2	8	3.41
	III	0	3
	IV	0	0
GI tract	I	8	3
	II	5	10
	III	5	6	0.66
	IV	1	2
Proctitis	I	10	9
	II	6	8
	III	3	3	0.01
	IV	0	0
Skin	I	5	3
	II	8	9
	III	12	11	0.00
	IV	0	0
Peripheral neuropathy	I	0	10
	II	0	4	1.09
	III	0	1
Bladder	I	12	11
	II	6	8
	III	2	1	0.27
	IV	0	0

P > 0.05. P value was calculated by subgroups for toxicity grade ≥ 3.