Extremely well-differentiated adenocarcinoma of the stomach: Clinicopathological and immunohistochemical features

Table 1 Phenotypic classification by immunohistochemical stains

				Human gastric mucin or MUC6
				(-)		(+)
	(+)			C - type
D10
	(-)		(+)
		MUC2			I - type
			(-)
				U - type		G - type

C: complete intestinal, I: incomplete intestinal, G: gastric, U: unclassified.

Table 2 Clinicopathological data

Case	Age	Sex	Loc	Size	Macro	Depth	ly	v	LN	Prognosis	Biopsy
Gastric phenotype
1	81	m	M	5.5	0-I	sm	(+)	(-)	NA	5 mo, alive	benign
2	51	m	U	2.5	0-IIa	sm	(-)	(-)	(-)	23 mo, alive	NA
3	63	m	M	8	1	ss	(-)	(-)	(-)	66 mo, alive	benign
4	76	m	U	3.5	1	ss	(-)	(+)	(-)	30 mo, alive	Ca, susp
5	57	m	U	5	1	ss	(+)	(-)	(-)	48 mo, alive	NA
Intestinal phenotype (incomplete intestinal-type)
6	65	f	M	1.5	0-IIa	sm	(+)	(-)	(-)	38 mo, alive	Ca, susp
7	45	m	M	2.4	1	mp	(-)	(-)	(-)	129 mo, alive	Ca, susp
(complete intestinal-type)
8	54	m	M	2.2	0-IIc	sm	(-)	(-)	(-)	136 mo, alive	Ca, susp
9	65	m	M	4	1	mp	(+)	(+)	(-)	30 mo, alive	Ca, susp

Loc: location (U: upper third, M: middle third), Macro: macroscopic feature, Depth: depth of invasion (sm: submucosa, mp: muscularis propria, ss: subserosa), ly: lymphatic permeation, v: venous invasion, LN: lymph node metastasis, NA: not assessed, Ca, susp: carcinoma, suspected.

Table 3 Previously reported cases of gastric EWDA

Case	Author		Age	Sex	Macro	Location	Size	Depth	ly	v	n	Prognosis	Phenotype	Biopsy
1	Araki	(1984)	50	m	1	M	45	ss	1	0	0	?	Incomp-I?	benign
2	Satoh	(1987)	65	m	1	U	40	mp	0	0	0	?	Comp-I?	benign
3	Yaosaka	(1989)	53	m	1	M	80	mp	2	0	1	?	Comp-I?	benign
4	Matsunaga	(1995)	42	m	0-I	L	45	sm	2	0	0	?	?	reg. Atypia
5	Kobayashi	(1999)	55	m	1	M	20	ss	0	0	0	?	Comp-I	Ca, susp
6	Endoh	(1999)	60	f	0-IIa+IIc	M	10	sm	0	0	0	?	Comp-I	Ca
7	Endoh	(1999)	68	f	0-IIc+IIb	M	20	sm	0	0	0	?	Comp-I	Ca
8	Endoh	(1999)	70	m	0-IIb	M	27	sm	0	0	0	?	Comp-I	NA
9	Endoh	(1999)	62	f	0-IIc+IIa	M	15	sm	0	0	0	?	Comp-I	NA
10	Endoh	(1999)	59	m	0-IIa	M	15	sm	0	0	0	?	Comp-I	Ca
11	Endoh	(1999)	74	m	0-IIa+IIc	L	18	sm	0	0	0	?	Comp-I	NA
12	Endoh	(1999)	70	m	0-IIa+IIc	M	25	sm	0	0	0	?	Comp-I	benign
13	Endoh	(1999)	65	m	1	M	55	se	0	0	0	?	Comp-I	benign
14	Adachi	(2000)	54	f	0-I	M	40	sm	?	1	0	?	I?	benign
15	Sato	(2004)	50	m	2	M	48	ss	2	1	0	?	Mixed	benign

Incomp-I: incomplete intestinal, Comp-I: complete intestinal, I: intestinal, reg. atypia: regenerative atypia (benign), NA: not assessed, Ca: carcinoma, Ca, susp: carcinoma, suspected, Macro: macroscopic type Location (U: upper third, M: middle third, L: lower third) Depth: depth of invastion (sm: submucosa, mp: muscularis propria, ss: subserosa).