Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong

Table 1 Characteristics of patients with GISTs

Characteristics		n (%)
Number of patients		47
Male/Female (ratio)		26:21 (1.23:1)
Mean age at the time of diagnosis(SD)		66.60 (SD 19.1)
Median follow up time in months (IQR)		26.00 (10-43)
Presenting symptoms
	GI bleeding	28 (60%)
	Epigastric pain	21 (45%)
	Abdominal mass	10 (21%)
	Incidental finding	3 (6.3%)
Locations
	Stomach	34 (72.3%)
	Small bowel	8 (17.0%)
	Esophagus	2 (4.3%)
	Colon	1 (2.1%)
	Omentum	2 (4.3%)
Resection1
	Complete	31 (66%)
	Incomplete	7 (14.9%)
	Inoperable	5 (10.6%)
Recurrence
(after initial surgery)	Total	4 (8.5%)
	Local recurrence	1 (2.1%)
	Distal metastasis	3 (6.4%)
Death	Total	16 (34%)
	Tumor related	11 (23.4%)
	Tumor unrelated	5 (10.6%)

¹Two patients refused resection of tumor. Two GISTs were discovered incidentally during autopsy. IQR: Inter-quartile range

Table 2 Tumor characteristics of 47 patients with GISTs

		n (%)
Number of patients		47
Median tumor size in cm (IRQ)		6.05 (3-7.5)
	≤5 cm	24 (51)
	>5-10 cm	13 (28)
	>10 cm	4 (9)
Mitotic index
	High	7 (15)
	Low	18(38)
	No	22(47)
Presence of distal metastasis or local invasion		7 (15)

Table 3 Univariate analyses of factors predicting GISTs recurrence or tumor related death

Prognostic factors	Hazard ratios	P value
Tumor size 5 cm or above	20.5	0.003
Presence of significant mitotic figures (1/10 HPF or above )	3.8	0.021
Presence of necrosis	4.4	0.005
Invasion to adjacent organ and/or presence of metastases at the time of diagnosis	16.5	<0.001
Incomplete tumor resection	4.6	0.002

Table 4 Multivariate analyses of factors predicting GISTs recurrence or tumor-related death

Prognostic factors	Hazard ratios (CI)	P value
Tumor size 5 cm or above	9.6 (1.1-86.0)	0.042
Invasion to adjacent organ and/or presence of metastases at the time of diagnosis	14.0 (2.5-78.6)	0.003
Incomplete tumor resection	2.1 (1.1-86.0)	0.032