Oxidative damage, pro-inflammatory cytokines, TGF-α and c-myc in chronic HCV-related hepatitis and cirrhosis

Table 1 Eight-hydroxydeoxyguanosine levels in chronic HCV-mediated liver damage (mean ± SD)

	n° 8OHdG/105 dG		n° 8OHdG/105 dG
CAH	42.3 ± 25.3	HCV genotype 1	74 ± 36
CIRR	73.64 ± 28.2	Other genotypes	46.9 ± 23
P	0.05		0.03

Table 2 TNF-α, IL-1β, TGF-α and c-myc expression in chronic HCV-mediated liver damage (mean ± SD)

	TNF-α/β-actin	IL-1β/β-actin	TGF-α/β-actin	c-myc/β-actin
CAH	0.7 ± 0.2	1.1 ± 0.3	0.41 ± 0.1	0.09 ± 0.05
CIRR	0.5 ± 0.2	1.4 ± 0.6	0.43 ± 0.2	0.46 ± 0.2
P	0.05	0.05	N.S.	0.001