Clinical features of hepatopulmonary syndrome in cirrhotic patients

Table 1 Characteristics and diagnostic values of signs and symptoms in hepatopulmonary syndrome

Symptomsand signs	Frequencyin HPS (%)		Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)	P
	Pos	Neg
Cyanosis	90	15.9	90	80.1	60	97	<0.0001
Clubbing	80	9.1	80	90.9	75	95	<0.0001
Dyspnea	100	25	100	75	50	100	<0.0001
Palmar erythema	80	29.5	80	70.5	38	94	0.003
Spider angioma	80	29.5	80	70.5	38	94	0.005

HPS: hepatopulmonary syndrome, PPV: positive predictive value, NPV: negative predictive value.

Table 2 Child class in hepatopulmonary syndrome and subclinical patients

Child classification	HPS positive	HPS negative	Total
Class A	0	5	5
Class B	2	27	29
Class C	8	12	20
Total	10	44	54

Table 3 Diagnostic value of arterial blood gases in hepatopulmonary syndrome

Laboratoryresults	Frequency(%)		Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)	P
	Pos	Neg
Pa02 < 70 and (A-a)02>30	100	4.5	100	92	85	100	< 0.0001
Pa02 < 70	100	4.5	100	95	83	100	< 0.0001
a02 < 65	70	4.5	70	98	77	95	< 0.0001
Pa02 < 60	30	4.5	30	92	66	87	0.039
(A-a)02>15	100	75	100	25	23	10	0.1
(A-a)02>20	100	63.6	100	36	26	100	0.24
(A-a)02>30	100	31.8	100	70	88	89	0.001
(A-a)02>40	90	11.4	90	88	65	75	< 0.0001
Orthodoxy>10	60	0	60	100	15	93	< 0.001