Hyperlactatemia in patients with non-acetaminophen-related acute liver failure

Table 1 Clinical and demographic characteristics of the patients

Age (yr)	32.7 ± 11
Sex (M/F)	26/37
Etiology (n, %)
Viral hepatitis	18 (30)
Cryptogenic (non-A, non-B, non-C)	32 (52)
Drug toxicity	7 (11)
MAOi	3
Rifampin+Isoniacid	2
Isoflurane	1
α metil-dopa	1
Metabolic disease	4 (6)
Encephalopathy
I-II (subacute form: 20 p)	20 (31.7)
III-IV (acute form:39 p) (hyperacute form: 4 p.)	43 (68)

Table 2 Plasma lactate levels at different sites (mean±SD)

	Total(n = 52)	Acute(n = 36)	Subacute(n = 16)	P
La (mmol/L)	4.1 ± 1.8 (1.1-15.2)	5.4 ± 1	2.2 ± 0.6	0.01
Lv (mmol/L)	4.3 ± 2 (1.4-16.3)	4.7 ± 2	2.4 ± 1.4	0.03
Lp (mmol/L)	5.3 ± 1.1a (2.1-17.6)	6.8 ± 1.8a	2.9 ± 0.9	<0.01
pH (units)	7.36 ± 0.07 (7.28-7.42)	7.33 ± 0.02	7.36 ± 0.04	NS
VACO2(mmHg)	12.4 ± 7 (8.3-13.4)	13.8 ± 5	9.6 ± 9	NS
AvpH (units)	0.06 ± 0.03 (0.02-0.07)	0.08 ± 0.02	0.07 ± 0.04	NS

La: arterial lactate; Lv: mixed venous lactate; Lp: portal vein lactate; L(a-p): transplanchnic arterial/portal difference of lactate; V_{A CO2}: portal/arterial gradient of CO²; AV_pH: arterial/portal gradient of pH; ^aP < 0.05 vs La, Lv and Lp.