Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take &ldquo;toll&rdquo;

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Mar 28, 2006 (publication date) through Oct 30, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2006; 12(12): 1829-1841
Published online Mar 28, 2006. doi: 10.3748/wjg.v12.i12.1829

Table 1 Locations of nine major loci showing linkage to inflammatory bowel disease

IBD locus	Chromosome	Identified genes	Disease
IBD1	16q13	NOD2/CARD15	CD
IBD2	12q14	Not known (VDR, STAT6, MMP18, b2-integrin)	UC
IBD3	6p	Not known (HLA, TNF)	IBD
IBD4	14q11-12	Not known (TCR, LTB4 receptor)	CD
IBD5	5q31-33	SLC22A4/A5	CD
IBD6	19p13	Not known (ICAM1, C3, TBXA2)	IBD
IBD7	1p36	Not known (TNF-R family)	IBD
IBD8	16p12	Not known	CD
IBD9	3p26	Not known (CCR5, CCR9,hMLH1)	IBD
	10q23	DLG5	IBD

Citation: Lakatos PL, Fischer S, Lakatos L, Gal I, Papp J. Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take “toll”. World J Gastroenterol 2006; 12(12): 1829-1841
URL: https://www.wjgnet.com/1007-9327/full/v12/i12/1829.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i12.1829