Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer

Table 1 Clinicopathological characteristics of rectal cancer patients studied

Male	33
Female	28
Age (yr)	54 (22–79)
Gross morphology
Fungating	14
Ulcerative	46
Infiltrative	1
Histologic type
Papillary adenocarcinoma	8
Tubular adenocarcinoma	52
Mucinous adenocarcinoma	1
Histologic grade
Well differentiated	8
Moderately differentiated	39
Poorly differentiated	14
Dukes’ stage
A	19
B	16
C	22
D	4

Table 2 Comparison of p53 immunostaining (IHC) and H&E staining in measuring the mean of DIS extents

DIS	IHC	H&E
0 cm	10	32
0.01 – 0.50 cm	26	26
0.51 – 1.00 cm	14	2
>1.00 cm	11	1
x	0.59 cm	0.13 cm
t	5.622
P	<0.0001

Table 3 Survival curves of groups A, B, C, and D

Group	Gehan value	P
A-B	1.204	0.273
A-C	1.685	0.194
A-D	5.359	0.021
B-C	0.814	0.367
B-D	4.627	0.032
C-D	1.124	0.289