Effect of 5-HT1 agonist (sumatriptan) on anorectal function in irritable bowel syndrome patients

Table 1 Effect of sumatriptan on manometric and volumetric anorectal parameters in IBS patients (mean ± SD)

Anorectal parameter	Placebo	Sumatriptan
Maximal resting pressure	9.2 ± 2.0 kPa	13.1 ± 3.3 kPab
Sphincter length during rest	4.0 ± 0.5 cm	4.5 ± 0.4 cmb
High pressure zone during rest	2.6 ± 0.3 cm	3.1 ± 0.5 cmb
Sphincter length during squeeze	5.1 ± 0.4 cm	5.4 ± 0.5 cmb
Urge sensation threshold	61 ± 19 mL	68 ± 18 mLb
First sensation threshold	27 ± 9 mL	34 ± 12 mLc
High pressure zone during squeeze	2.8 ± 0.6 cm	3.0 ± 0.7 cmc
Pain threshold: ≤100mL/>100mL (number of patients)	13/9	8/14
Rectoanal inhibitory reflex (RAIR)	21 ± 8 mL	21 ± 9 mL
Straining test results:
Proper relaxation/lack of relaxation/ contraction (number of patients)	14/7/1	13/8/1
Maximal squeeze pressure	25.5 ± 8.5 kPa	27.2 ± 8.4 kPa
Maximal cough pressure/maximal resting pressure	2.9 ± 0.8	3.1 ± 1.1

^bP<0.01,

^cP<0.05, vs Placebo. Paired Student’s t test was used in all cases except for analysis of straining test results and pain thresholds where chi-square test was used.