Liver cirrhosis as a consequence of iron overload caused by hereditary nonspherocytic hemolytic anemia

Table 1 Laboratory parameters of the described patients at admission.

Liver inflammationand function	Normal	Patient 1	Patient 2
ALT (GOT),	520 U/L	30 U/L	31 U/L
AST (GPT)	525 U/L	39 U/L	41 U/L
g-GT	530 U/L	41 U/L	61 U/L
Alkaline phosphatase	<180 U/L	224 U/L	219 U/L
Prothrombin time	70-110%	48%	102%
INR		1.43	0.99
Albumin	(3.65.0 g/dL)	2.9 mg/dL	4.4 mg/dL
Cholinesterase	(3.57.0 kU/L)	2.1 kU/L	4.8 kU/L
C-reactive protein	<0.7 mg/dL	10 mg/dL	0.5 mg/dL
Erythrocyte morphology		anisocytosis,	macrocytosis,
		poikilocytosis,	anisocytosis,
		acanthocytosis	poikiLocytosis
Blood count, parameters of hemolysis and iron metabolism
WBC	(310/nL)	24 /nL	13 /nL
Hemoglobin	(13.5-16 g/dL)	9.2 g/dL	11.5 g/dL
Free hemoglobin	(35-65 mg/dL)	150 mg/L	115 mg/L
Total bilirubin	(0.4-1.0 mg/dL)	8.3 mg/dL	7.6 mg/dL
Direct bilirubin	(0.2-0.5 mg/dL)	1.7 mg/dL	0.8 mg/dL
Haptoglobin	(<0.23 g/L)	< 0.233 g/L	< 0.233 g/L
Lactat-dehydrogenase	(10-150 U/L)	450 U/L	375 U/L
Reticulocytes	(<1%)	21%	22%
Ferritin	(15630 ng/mL)	1850 ng/mL	1620 ng/mL
Urine iron excretion		0.5 mg/24 h	0.3 mg/24 h