Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer

Table 1 Correlations between MC and macrophages infiltration and the various clinicopathologic factors.

	MCs		TAMs
	High1	Low2	High3	Low4
Age (yr)5 Sex7	61.2	57.2	58.3	59.7
Male	13	22	16	19
Female	14	11	13	12
Histological grade of carcinoma6
Well	12	9	14	10
Moderate	11	14	12	12
Poor	4	10	3	9
Depth of invasion7
Superficial Ta-T1	19b	10	19d	9
Invasive T2-T4	8b	23	10d	22
Lymph node metastasis7
Positive	11a	24	12c	22
Negative	16a	9	17c	9
Distant metastasis7
Positive	7a	17	8c	18
Negative	20a	16	21c	13

¹Patients with a high level of MCs infiltration.

²Patients with a low level of MCs infiltration.

³Patients with a high level of TAMs infiltration.

⁴Patients with a low level of TAMs infiltration.

⁵Student’s t-test.

⁶Mann-Whitney test. 7χ2 test.

^aP<0.05,

^bP<0.01,

^cP<0.05,

^dP<0.01.

Table 2 Proportion of MC_T and MC_TC in colorectal cancer and normal.

	MCTC (mean±SD)	MCT (mean±SD)	Total
Normal group (n = 20)	10.13.2 (74.3%)	3.50.9 (25.7%)	13.62.1 (100%)
Colorectal cancer group (n=60)	45.810.6 (77.4%)	13.44.9 (22.6%)	59.29.3 (100%)

MC_T, mast cell positive for tryptase. MC_TC, mast cell positive for tryptase and chymase. The percentage of MCr and MCrc was not significant in both groups (P>0.05, χ² test).

Table 3 Proportion of MC_T and MC_TC in colorectal cancer with various histological grades.

Histological grade of carcinoma	MCTC (mean±SD)	MCT (mean±SD)	Total
Well (n = 21)	50.812.5 (80.5%)	12.35.1 (19.5%)	63.110.1 (100%)
Moderate (n = 25)	42.29.1 (73.0%)	15.63.3 (27.0%)	57.88.2 (100%)
Poor (n = 14)	44.78.5 (80.0%)	11.24.7 (20.0%)	55.95.3 (100%)

MC_T, mast cell positive for tryptase. MC_TC, mast cell positive for tryptase and chymase. The percentage of MCr and MCrc was not significant in every group (P>0.05. χ² test).