Protective effect of Weikang decoction and partial ingredients on model rat with gastric mucosa ulcer

doi:10.3748/wjg.v11.i8.1204

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Feb 28, 2005 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2005; 11(8): 1204-1209
Published online Feb 28, 2005. doi: 10.3748/wjg.v11.i8.1204

Table 1 Thickness of mucus on gastric mucosa surface and the content of EGF in gastric juice (mean±SD).

Group	Specimens	Thickness of mucus (mm)	EGF (ng/g)
Control	10	64.1±9.3^b^d	2.168±0.375^b
Model	10	23.2±8.4	0.818±0.18
WK (20 g/kg)	10	51.3±2.9^b^d	1.364±0.12^a
WK (10 g/kg)	10	43.3±2.9^b^c	1.359±0.24^a
WK (5 g/kg)	9	36.1±7.2^b	1.245±0.31^a
Jianpiyiqi	7	35.4±5.6^b	1.025±0.45^c
Yangxuehuoxue	10	33.1±8.9^b	1.03±0.29^c
Qingrejiedu	9	31.0±8.0	1.02±0.47^c
CBP capsules	10	38.2±3.5^b	1.237±0.20^a

^aP<0.05,

^bP<0.01 vs the model group,

^cP<0.05,

^dP<0.01 vs CBP capsules.

Table 2 Content of NO in gastric tissue and the content of ET in plasma (mean±SD).

Group	Specimens	NO (mmol/g)	ET (pg/mL)
Control	10	0.601±0.081^b^d	46.64±21.20^b^d
Model	10	0.213±0.049	179.96±37.40
WK 20 g/kg	10	0.480±0.026^b^c	81.30±17.20^b
WK 10 g/kg	10	0.390±0.055^a	83.40±25.90^b
WK 5 g/kg	9	0.394±0.026^a	93.87±20.70^b
Jianpiyiqi	7	0.393±0.123^a	130.67±43.66^b^c
Yangxuehuoxue	10	0.463±0.077^b^c	115.88±34.09^b^c
Qingrejiedu	9	0.382±0.082^a	108.22±36.97^b
CBP capsules	10	0.395±0.053^a	91.96±19.0^b

^aP<0.05,

^bP<0.01 vs the model group,

^cP<0.05,

^dP<0.01 vs CBP capsules.

Table 3 Content of SOD and MDA in plasma of each group (mean±SD).

Group	Specimens	SOD (NU/mL)	f MDA (NM/mL)
Control	10	196.6±35.3^b^d	15.7±4.8^b^d
Model	10	128.6±15.0	48.2±4.5
WK 20 g/kg	10	186.4±19.9^b^d	21.6±7.4^b^c
WK 10 g/kg	10	168.2±21.7^a^c	32.2±7.3^a
WK 5 g/kg	9	155.6±21.6^a	34.2±6.2^a
Jianpiyiqi	7	168.0±85.3^a^c	34.9±13.8^a
Yangxuehuoxue	10	165.0±34.0^a^c	35.5±16.7^a
Qingrejiedu	9	168.2±24.9^a^c	42.2±17.6^a^c
CBP capsules	10	156.3±18.1^a	30.1±6.1^a

^aP<0.05,

^bP<0.01 vs the model group,

^cP<0.05,

^dP<0.01 vs CBP capsules.

Table 4 Effect of WK on the content of 6-K-PGF1α in plasma in rats (mean±SD).

Group	Specimens	6-K-PGF₁a (pg/mL)
Control	10	96.6±8.3^b
Model	10	59.7±6.3
WK 20 g/kg	10	86.8±7.6^b
WK 10 g/kg	10	77.9±7.0^a
WK 5 g/kg	9	70.0±5.4^a
Jianpiyiqi	7	73.5±12.2^a
Yangxuehuoxue	10	65.1±5.3
Qingrejiedu	9	76.9±14.6^a
CBP capsules	10	93.7±10.7^b

^aP<0.05,

^bP<0.01 vs the model group.

Citation: Fan TY, Feng QQ, Jia CR, Fan Q, Li CA, Bai XL. Protective effect of Weikang decoction and partial ingredients on model rat with gastric mucosa ulcer. World J Gastroenterol 2005; 11(8): 1204-1209
URL: https://www.wjgnet.com/1007-9327/full/v11/i8/1204.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i8.1204