Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance

Table 1 Clinicopathologic characteristics of colorectal cancer with expression of COX-2.

Variable	n	COX-2 positive n (%)	COX-2 negative n (%)
Sex
Male	73	50 (68.5)	23 (31.5)
Female	55	37 (67.3)	18 (32.7)
Age (yr)		54±12	56±15
Histological differentiation
Well	26	17 (65.4)	9 (34.6)
Moderate	57	40 (70.2)	17 (29.8)
Poor	45	30 (66.7)	15 (33.3)
Depth of invasion
T1-T2	81	48 (59.3)	33 (40.7)
T3-T4	47	39 (83.0)	8 (17.0)a
Metastasis
Present	50	42 (84.0)	8 (16.0)
Absent	78	45 (57.7)	33 (42.3)a
Dukes stage
I	37	15 (40.5)	22 (59.5)
II	41	28 (68.3)	13 (31.7)
III+IV	50	44 (88.0)	6 (12.0)a
VEGF expression
Positive	49	40 (81.6)	9 (18.4)
Negative	79	47 (59.5)	32 (40.5)a
MMP-2 expression
Positive	88	70 (79.6)	18 (20.4)
Negative	40	17 (42.5)	23 (57.5)a

^aP<0.05 vs positive.