Detection of CK20mRNA in peripheral blood of pancreatic cancer and its clinical significance

Table 1 Associations between CK20mRNA and clinicopathologic variables in pancreatic cancer (Fisher’s exact test).

Variable	n	CK20 (+)	CK20 (-)	P-value
Sex
Male	28	16	12	0.612
Female	12	7	5
Age (yr)
≥65	19	9	10	0.218
<60	21	14	7
Tumor size
≥3 cm	30	17	13	0.577
<3 cm	10	6	4
Tumor differentiation
High differentiation	14	4	10	0.009
Moderate+poor	26	19	7
Lymph node metastasis
Negative	10	2	8	0.008
Positive	30	21	9
Tumor stage (TNM)
II	11	3	8	0.021
III	29	20	9
Depth of tumor invasion
T1-T2	12	5	7	0.164
T3-T4	28	18	10

Table 2 CK20mRNA expression and cumulative tumor metastasis after operation (Fisher’s exact test).

CK20mRNA expression	n	Within 6 mo	Within 12 mo	Within 24 mo
Positive	23	8 (34.7%)	17 (73.9%)	19 (82.6%)
Negative	17	1 (5.9%)	6 (35.3%)	13 (76.5%)
P-value		0.043	0.02	0.631

Table 3 CK20mRNA expression and survival time after operation.

CK20mRNA expression	Disease-free survival time		Overall survival time
	Median (mo)	95%CI	Median (mo)	95%CI
Positive	10	5.97-14.21	15	13.93-16.07
Negative	16	11.36-20.64	23	17.15-28.85

Kaplan-Meier method, 95%CI (95% confidence interval).