Analysis of prognosis on patients with severe viral hepatitis using the model for end-stage liver disease

Table 1 Patients’ demographics.

	PE group	Non-PE group
Sex (male/female)	Jul-53	Mar-58
Age (yr)
Median (range)	42 (18-65)	40 (18-68)
Etiology (cases)
B	45	41
B+E	13	16
B+C	2	4
Clinical type (cases)
Subacute severe hepatitis	9	6
Chronic severe hepatitis	51	55
Laboratory parameters
Serum total bilirubin (mmol/L)	588.88	514.99
(Range)	(217.0-1 015.5)	(293.0-1 140.3)
Serum creatinine (mmol/L)	131.63	142.09
(Range)	(43.3-401.8)	(42.0-945.0)
INR1	3.18	2.88
(Range)	(1.90-6.60)	(1.91-7.20)

¹International normalized ratio (INR).

Table 2 Comparison of clinical biochemical data and MELD score between PE group and non-PE group before treatment (mean±SD).

	20 ≤MELD<30		30 ≤MELD<40		MELD≥40
	PE group	Non-PE group	PE group	Non-PE group	PE group	Non-PE group
Bilirubin (mmol/L)	561.66±148.92	463.28±169.69	606.40±150.60	526.44±148.00	600.77±140.90	677.79±221.18
INR	2.13±0.62	2.34±0.67	3.54±1.16	4.14±1.24	4.01±1.58	3.58±1.69
Creatinine (mmol/L)	70.53±18.69	72.51±26.11	106.45±37.31	101.97±65.85	237.12±136.64	523.01±289.10
MELD score	24.7±3.1	24.2±3.0	34.7±2.2	32.4±7.1	42.7±1.7	48.6±5.3

Table 3 Changes in related data of the PE group between before and after the plasma exchange (mean±SD).

	20 ≤MELD<30		30 ≤MELD<40		MELD≥40
	Before PE	After PE	Before PE	After PE	Before PE	After PE
Bilirubin (mmol/L)	561.66±148.92	242.01±134.39b	606.40±150.60	260.85±64.65b	600.77±140.90	289.70±147.50b
INR	2.13±0.62	1.55±0.28a	3.54±1.16	1.59±0.22a	4.01±1.58	2.40±1.52a
Creatinine (mmol/L)	70.53±18.68	88.00±21.28	106.45±37.31	124.78±41.22	237.12±136.64	228.38±132.04
MELD score	24.7±3.1	19.7±3.5 a	34.7±2.2	22.7±3.7a	42.7±1.7	28.4±5.3a

^aP<0.05, after PE vs before PE;

^bP<0.01, after PE vs before PE.

Table 4 Three-month death rates.

	20 ≤MELD<30	30 ≤MELD<40	MELD≥40
Non-PE group	67.6% (25/37)	81.3% (13/16)	100% (8/8)
PE group	31.6% (6/19)a	57.7% (15/26)c	93.3% (14/15 )1

χ² = 6.58,

^aP<0.05, PE group vs non-PE group; χ² = 3.97,

^cP<0.05, PE group vs non-PE group;

¹P = 0.65, PE group vs non-PE group.

Table 5 Four-fold table analysis of diagnostic experiment.

Real prognosis	Predicted prognosis
	Number of deaths	Number of survivors
Number of deaths	Value of true positivea	Value of false negativeb
Number of survivors	Value of false positivec	Value of true negatived

Sensitivity = a/(a+b)×100%, specificity = d/(c+d)×100%.