Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line

Table 1 Cell cycle distribution of SW480 cells transfected with telomerase ASODNs, SODNs and Oligofectamine^TM (mean±SD, n = 3).

	Cell cycle distribution (%)
	G0/G1	S	G2/M
Control	50.7±2.3	36.6±1.8	15.5±2.2
OligofectamineTM	53.8±2.7	34.1±3.6	12.3±2.6
S-hTR	53.1±2.8	34.4±13.2	12.5±1.3
S-hTERT	50.7±3.5	30.1±2.8	19.2±2.6
Anti-hTR	55.0±2.3	30.1±2.5	14.9±1.9
Anti-hTERT	49.2±3.4	28.8±3.1	21.9±2.8b
Anti- hTR+anti-hTERT	63.8±2.3b	24.9±1.6	12.3±2.9

^bP<0.01 vs control group.