Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma

Table 1 Expression of leptin and ob-R in gastric cancer and precancerous lesions

	n	Leptin					Ob-R					Dualexpression ofleptinand
				+	++	++				++	+++	ob-R
		-	+	+	+	++	-	+	++	+	+	n	(%)
Intestinal	30	5	4	5	17	0	4	5	7	14	0	25	(83.3)
metaplasia
Gastric	90	6	12	28	39	0	9	15	25	35	4	79	(87.7)
dysolasia
Gastric	90	25	9	16	16	24	24	9	22	12	25	75	(83.3)
cancer

For comparison of positive percentage for dusl expression of loptin and ob-R among (1)intestinal metaplsia (2)gastric dysplasia (3)gastric carcinoma, (1)vs(2) χ² = 0.3864, P=0.5351; (1)vs(3) χ² = 0.3864, P = 1.000; (2)vs(3) χ² = 0.7193, P = 0.3964

Table 2 Expression of leptin and ob-R in mild, moderate, and severe gastric

	n	Leptin					Ob-R					Dualexpression ofleptinand
				+	++	++				++	+++	ob-R
		-	+	+	+	++	-	+	++	+	+	n	(%)
Mild	30	3	6	9	12	0	4	8	9	9	0	25	(83.3)
dysplasia
Moderate	30	3	2	12	10	3	3	3	9	13	2	26	(86.7)
dysplasia
Severe	30	0	4	7	17	2	2	4	7	15	2	28	(93.3)
dysplasia

For comparison of positive percentage for dusl expression of loptin and ob-R among (1)mild gastric dysplasia (2)moderate gastric dysplasia (3)severe gastric dysplasia, (1)vs(2) χ² = 0.1307, P = 0.7177; (1)vs(3) χ² = 1.456, P = 0.2276; (2)vs(3) χ² = 0.7407, P = 0.3894

Table 3 Expression of leptin and ob-R in intestinal-type and diffuse-type gastric cancer

	n	Leptin					Ob-R					Dualexpression ofleptinand
				+	++	++				++	+++	ob-R
		-	+	+	+	++	-	+	++	+	+	n	(%)
Intestinal-type	60	4	6	11	15	24	5	7	15	10	25	75	(91.7)
GC1
Diffuse-type	30	21	3	5	1	0	19	2	7	2	0	9	(30)
GC1

¹GC-gastric cancer for comparison of positive percentage for dual expression of leptin and ob-R between intestinal-type gastric carcinoma and diffuse-type gastric carcinoma, χ² = 37.022, P<0.001.