Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2005; 11(47): 7525-7530
Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7525
Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7525
Table 1 Demographic characteristics and clinical features of 120 patients with Crohn’s disease and of 85 patients with ulcerative colitis
Crohn’s disease | Ulcerative colitis | |
Total number | 120 | 85 |
Sex (male/female) | 58/62 | 42/43 |
Age of diagnosis (mean±SD yr) | 29.82±14.00 | 33.36±14.24 |
Family history in first-degree relative (%) | 4 (3.3 %) | 5 (5.9%) |
Smoking habit (%) | ||
Never | 50 (41.7%) | 48 (56.5%) |
Ex-smoker | 11 (9.2%) | 14 (16.5%) |
Current | 59 (49.2%) | 23 (27.1%) |
Localization of disease | ||
Ileal | 39 (32.5%) | |
Colonic | 11 (9.2%) | |
Ileocolitis | 67 (55.8%) | |
Upper gastroenteric | 3 (2.5%) | |
Disease features | ||
Inflammatory | 78 (65%) | |
Fibrostenotic | 32 (26.7%) | |
Fistulizing | 10 (8.3%) | |
Extra-intestinal manifestations | ||
Arthritis | 16 (13.3%) | |
Erythema nodosum | 5 (4.2%) |
Table 2 Allele and genotype frequencies of C1672T SNP in OCTN1 gene in CD and UC patients and in healthy controls
Alleles | Genotypes | ||||||||
C | T | T allele frequencies (%) | P | CC | CT | TT | TT genotype frequencies (%) | P | |
[odds ratio (95%CI)] | [odds ratio (95%CI )] | ||||||||
CD | 180 | 60 | 25 | 0.01 [1.89 (1.16–3.07)] | 70 | 40 | 10 | 8.33 | 0.095 [2.94 (0.78–10.99)] |
UC | 151 | 19 | 11.17 | 0.28 [0.71 (0.38–1.32)] | 67 | 17 | 1 | 1.17 | 0.39 [0.38 (0.04–3.77)] |
Controls | 170 | 30 | 15 | 73 | 24 | 3 | 3 |
Table 3 Allele and genotype frequencies of G-207C SNP in OCTN2 gene in CD and UC patients and in healthy controls
Alleles | Genotypes | ||||||||
G | C | C allele frequencies (%) | P | GG | GC | CC | CC genotype frequencies (%) | P | |
[odds ratio (95%CI)] | [odds ratio (95%CI)] | ||||||||
CD | 188 | 52 | 21.67 | 0.038 [1.69 (1.02–2.81)] | 75 | 38 | 7 | 5.83 | 0.53 [1.49 (0.42–5.23)] |
UC | 152 | 18 | 10.58 | 0.32 [0.73 (0.39–1.37)] | 69 | 14 | 2 | 2.35 | 0.53 [0.58 (0.10–3.24)] |
Controls | 172 | 28 | 14 | 76 | 20 | 4 | 4 |
Table 4 Linkage disequilibrium (D’ and r2 between 1672T and -207C are indicated), and TC haplotype frequencies in patients with CD, UC and in healthy individuals
Number of patients | D’ | r2 | TC haplotype frequencies (%) | P | |
[odds ratio (95%CI)] | |||||
CD | 120 | 0.51 | 0.22 | 13.3 | 0.018 [2.21 (1.12–4.43)] |
UC | 85 | 0.5 | 0.23 | 5.9 | 0.81 [0.89 (0.37–2.15)] |
Controls | 100 | 0.34 | 0.1 | 6.5 |
Table 5 Odds ratios for susceptibility to CD and UC of a NOD2/CARD15 mutation, and for the joint TC- NOD2/CARD15 effect
Odds ratios | |||
TC | NOD2/CARD15 | Joint TC- NOD2/CARD15 | |
CD | 2.21 (1.12–4.43) P = 0.018 | 16.8 (8.6–32.7) P < 0.0001 | 9.22 (2.1–40.6) P = 0.0005 |
UC | 0.89 (0.37–2.15) P = 0.79 | 3.34 (1.76–6.36) P = 0.0002 | 3.06 (0.58–16.21) P = 0.17 |
- Citation: Gazouli M, Mantzaris G, Archimandritis AJ, Nasioulas G, Anagnou NP. Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn’s disease. World J Gastroenterol 2005; 11(47): 7525-7530
- URL: https://www.wjgnet.com/1007-9327/full/v11/i47/7525.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i47.7525