Rapid Communication
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2005; 11(47): 7525-7530
Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7525
Table 1 Demographic characteristics and clinical features of 120 patients with Crohn’s disease and of 85 patients with ulcerative colitis
Crohn’s diseaseUlcerative colitis
Total number12085
Sex (male/female)58/6242/43
Age of diagnosis (mean±SD yr)29.82±14.0033.36±14.24
Family history in first-degree relative (%)4 (3.3 %)5 (5.9%)
Smoking habit (%)
Never50 (41.7%)48 (56.5%)
Ex-smoker11 (9.2%)14 (16.5%)
Current59 (49.2%)23 (27.1%)
Localization of disease
Ileal39 (32.5%)
Colonic11 (9.2%)
Ileocolitis67 (55.8%)
Upper gastroenteric3 (2.5%)
Disease features
Inflammatory78 (65%)
Fibrostenotic32 (26.7%)
Fistulizing10 (8.3%)
Extra-intestinal manifestations
Arthritis16 (13.3%)
Erythema nodosum5 (4.2%)
Table 2 Allele and genotype frequencies of C1672T SNP in OCTN1 gene in CD and UC patients and in healthy controls
Alleles
Genotypes
CTT allele frequencies (%)PCCCTTTTT genotype frequencies (%)P
[odds ratio (95%CI)][odds ratio (95%CI )]
CD18060250.01 [1.89 (1.16–3.07)]7040108.330.095 [2.94 (0.78–10.99)]
UC1511911.170.28 [0.71 (0.38–1.32)]671711.170.39 [0.38 (0.04–3.77)]
Controls1703015732433
Table 3 Allele and genotype frequencies of G-207C SNP in OCTN2 gene in CD and UC patients and in healthy controls
Alleles
Genotypes
GCC allele frequencies (%)PGGGCCCCC genotype frequencies (%)P
[odds ratio (95%CI)][odds ratio (95%CI)]
CD1885221.670.038 [1.69 (1.02–2.81)]753875.830.53 [1.49 (0.42–5.23)]
UC1521810.580.32 [0.73 (0.39–1.37)]691422.350.53 [0.58 (0.10–3.24)]
Controls1722814762044
Table 4 Linkage disequilibrium (D’ and r2 between 1672T and -207C are indicated), and TC haplotype frequencies in patients with CD, UC and in healthy individuals
Number of patientsDr2TC haplotype frequencies (%)P
[odds ratio (95%CI)]
CD1200.510.2213.30.018 [2.21 (1.12–4.43)]
UC850.50.235.90.81 [0.89 (0.37–2.15)]
Controls1000.340.16.5
Table 5 Odds ratios for susceptibility to CD and UC of a NOD2/CARD15 mutation, and for the joint TC- NOD2/CARD15 effect
Odds ratios
TCNOD2/CARD15Joint TC- NOD2/CARD15
CD2.21 (1.12–4.43) P = 0.01816.8 (8.6–32.7) P < 0.00019.22 (2.1–40.6) P = 0.0005
UC0.89 (0.37–2.15) P = 0.793.34 (1.76–6.36) P = 0.00023.06 (0.58–16.21) P = 0.17