Viral Hepatitis
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2005; 11(47): 7494-7498
Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7494
Table 1 Demographic characteristics of 371 study subjects with and without chronic hepatitis C (CH-C)
CH-C patients(n = 182)Controls(n = 189)P
Mean age (yr)59.9±12.958.8±13.90.302
Sex (male:female)91:91106:830.254
Educational status (below high school:high school or above)97:8562:127<0.001
Subjective difficulty to questionnaire(difficult:non difference:easy)0.1460.3620.118
Acute illness during recent two weeks (yes:no)47:13547:1420.905
Combined chronic diseases (yes:no)94:88115:740.076
Table 2 Mean scores of eight domains of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in subjects with and without chronic hepatitis C (CH-C)
SF-36 domainsCH-C patients(n = 182)Non CH-C control group(n = 189)P
General health49.0±19.959.7±19.4<0.001
Physical functioning63.1±18.982.7±18.4<0.001
Role-physical58.0±43.969.6±40.30.008
Role-emotional62.4±44.372.5±40.60.03
Social functioning81.0±17.282.9±14.20.568
Body pain72.3±16.970.5±17.60.319
Vitality56.2±19.964.4±17.0<0.001
Mental health66.2±14.970.1±14.40.008
Table 3 Characteristics and mean scores of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in 47 CH-C subjects before initiation of antiviral treatment
ItemsOverallsubjects(n = 47)Non-sustainedvirologicalresponder(n = 26)Sustainedvirologicalresponder(n = 21)P
Age (yr)48.6±10.948.9±11.648.1±10.20.974
Sex (male:female)41:06:0024:02:0017:040.386
General health56.3±18.154.2±20.258.9±15.10.577
Physical functioning74.6±15.875.0±11.374.0±20.30.352
Role-physical77.7±34.776.9±30.878.6±39.80.343
Role-emotional74.5±38.273.1±37.776.2±39.60.631
Social functioning73.4±14.669.7±14.778.1±13.40.072
Body pain73.5±18.871.5±19.875.9±17.60.322
Vitality56.8±17.052.9±15.961.7±17.40.067
Mental health65.6±15.861.5±13.670.7±17.20.024
Table 4 Comparison of mean scores of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in 21 sustained virological responders at different time points of antiviral treatment1
SF-36 domains/stagesBefore treatmentAt 12th wkof treatmentAt the end of TreatmentAt the 6th moafter stopping treatment
General health58.9±19.159.1±19.567.9±11.5a86.9±12.9b
Physical functioning74.0±20.371.9±19.076.0±17.483.9±3.6a
Role-physical78.6±39.877.4±40.291.7±24.1100.0±0a
Role-emotional76.2±39.674.6±43.387.3±30.798.2±7.6a
Social functioning78.1±13.467.5±12.4a72.0±11.889.9±10.9b
Body pain75.9±17.667.4±21.377.1±15.394.1±10.9b
Vitality61.7±17.460.0±14.063.1±16.081.0±8.5b
Mental health70.7±17.265.7±11.067.0±16.082.9±6.7b
Table 5 Comparison of mean scores of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in 26 non-sustained virological responders at different time points of antiviral treatment1
SF-36 domains/stagesBefore treatmentAt the 12th wk of treatmentAt the end of treatmentAt the 6th mo after stopping treatment
General health54.2±20.246.2±16.2b53.1±19.754.1±19.3
Physical functioning75.0±11.359.2±17.8b68.9±12.775.7±8.7
Role-physical76.9±30.851.9±43.0b77.2±31.976.1±31.5
Role-emotional73.1±37.751.3±45.4a68.1±39.565.2±42.0
Social functioning69.7±14.760.1±19.0b71.7±15.669.0±17.6
Body pain71.5±19.855.8±24.4b67.2±17.167.7±24.0
Vitality52.9±15.946.0±17.4a52.8±18.055.0±14.5
Mental health61.5±13.653.5±15.3a60.5±14.661.7±15.3