Kang SC, Hwang SJ, Lee SH, Chang FY, Lee SD. Health-related quality of life and impact of antiviral treatment in Chinese patients with chronic hepatitis C in Taiwan. World J Gastroenterol 2005; 11(47): 7494-7498 [PMID: 16437722 DOI: 10.3748/wjg.v11.i47.7494]
Corresponding Author of This Article
Shinn-Jang Hwang, MD, F.A.C.G., Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Shih-Pai Road Sec. 2, Taipei 112, Taiwan, China. sjhwang@vghtpe.gov.tw
Article-Type of This Article
Viral Hepatitis
Open-Access Policy of This Article
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World J Gastroenterol. Dec 21, 2005; 11(47): 7494-7498 Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7494
Table 1 Demographic characteristics of 371 study subjects with and without chronic hepatitis C (CH-C)
CH-C patients(n = 182)
Controls(n = 189)
P
Mean age (yr)
59.9±12.9
58.8±13.9
0.302
Sex (male:female)
91:91
106:83
0.254
Educational status (below high school:high school or above)
97:85
62:127
<0.001
Subjective difficulty to questionnaire(difficult:non difference:easy)
0.146
0.362
0.118
Acute illness during recent two weeks (yes:no)
47:135
47:142
0.905
Combined chronic diseases (yes:no)
94:88
115:74
0.076
Table 2 Mean scores of eight domains of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in subjects with and without chronic hepatitis C (CH-C)
SF-36 domains
CH-C patients(n = 182)
Non CH-C control group(n = 189)
P
General health
49.0±19.9
59.7±19.4
<0.001
Physical functioning
63.1±18.9
82.7±18.4
<0.001
Role-physical
58.0±43.9
69.6±40.3
0.008
Role-emotional
62.4±44.3
72.5±40.6
0.03
Social functioning
81.0±17.2
82.9±14.2
0.568
Body pain
72.3±16.9
70.5±17.6
0.319
Vitality
56.2±19.9
64.4±17.0
<0.001
Mental health
66.2±14.9
70.1±14.4
0.008
Table 3 Characteristics and mean scores of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in 47 CH-C subjects before initiation of antiviral treatment
Items
Overallsubjects(n = 47)
Non-sustainedvirologicalresponder(n = 26)
Sustainedvirologicalresponder(n = 21)
P
Age (yr)
48.6±10.9
48.9±11.6
48.1±10.2
0.974
Sex (male:female)
41:06:00
24:02:00
17:04
0.386
General health
56.3±18.1
54.2±20.2
58.9±15.1
0.577
Physical functioning
74.6±15.8
75.0±11.3
74.0±20.3
0.352
Role-physical
77.7±34.7
76.9±30.8
78.6±39.8
0.343
Role-emotional
74.5±38.2
73.1±37.7
76.2±39.6
0.631
Social functioning
73.4±14.6
69.7±14.7
78.1±13.4
0.072
Body pain
73.5±18.8
71.5±19.8
75.9±17.6
0.322
Vitality
56.8±17.0
52.9±15.9
61.7±17.4
0.067
Mental health
65.6±15.8
61.5±13.6
70.7±17.2
0.024
Table 4 Comparison of mean scores of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in 21 sustained virological responders at different time points of antiviral treatment1
Table 5 Comparison of mean scores of Short Form 36 (SF-36) Health-related Quality of Life (HRQOL) Questionnaire in 26 non-sustained virological responders at different time points of antiviral treatment1
Citation: Kang SC, Hwang SJ, Lee SH, Chang FY, Lee SD. Health-related quality of life and impact of antiviral treatment in Chinese patients with chronic hepatitis C in Taiwan. World J Gastroenterol 2005; 11(47): 7494-7498