Accuracy of a predictive model for severe hepatic fibrosis or cirrhosis in chronic hepatitis C

Table 1 Determinants of Bonacini score

Laboratory	Score
parameters	0	1	2	3	4	5	6
INR	<1.1	1.1-1.4	>1.4
ALT/AST ratio	>1.7	1.7-1.2	1.19-0.6	<0.6
PLT ×1 000 /mm3	>340	340-280	279-220	219-160	159-100	99-40	<40

Table 2 Clinical and biochemical characteristics of 176 consecutive patients with chronic hepatitis C included in

	#	%	Mean±SD
Age (yr)			53.5±21.2
Sex: Male	96	55
Female	80	45
BMI (kg/m2)			25.9±2.9
<25	90	51
≥25	86	49
Alcohol intake (g/d)
≤30	142	80
31-80	24	14
>80	10	6
HCV genotype
1	92	52
2	60	34
3	19	11
4	5	3
Platelet count			181±128
AST (IU/L)			78.5±101
ALT (IU/L)			125±178
AST/ALT			1.6±1.1
INR			1.05±0.1
Hemoglobin (g/dL)			14.5±2.1
Albumin (g/dL)			4.5±0.6
Bilirubin (mg/dL)			0.9±0.2

Table 3 Distribution of 176 patients according to Bonacini score and pre-defined grouping

Bonacini score	≤3	4-7	>7
LSN	-ve	-ve	-ve
	+ve	+ve	+ve
Patients (#)	56	49	0
	8	59	4
Pre-defined	I	III	V
group1	II	IV
F 3-4	1/56	14/49	0
Patients (#)	4/8	44/59	4/4
Observed (%)	2	29	100
Expected2 (%)	50	76	99
	6	21
	66	86

¹See text and Figure 1;

²As from Table 1.