Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis

Table 1 Clinical and outcome data in 50 patients with acute pancreatitis

	Number of patients	Percentage
Male/female	25/25
Age, yr, mean (SD)	62.5 (16.5)
Etiology
Gallstones	30	60
Idiopathic	12	24
Alcohol	3	6
Post-ERCP	3	6
Hypertriglyceridemia	2	4
Severity
Severe	15	30
Mild	35	70
Complications
Local	12	24
Systemic	17	34
Death	5	10

ERCP, endoscopic retrograde cholangiopancreatography.

Table 2 Etiology in 22 controls with non-pancreatic acute abdomen

Etiology	Number of patients	Percentage
Acute cholecystitis	5	22.7
Acute appendicitis	3	13.6
Coliky pain	3	13.6
Intestinal obstruction	2	9.1
Active Crohn’s disease	2	9.1
Acute cholangitis	1	4.5
Perforated peptic ulcer	1	4.5
Gastric carcinoma	1	4.5
Epiploic appendicitis	1	4.5
Abdominal abscess	1	4.5
Bleeding peptic ulcer	1	4.5
Mesenteric lymphadenitis	1	4.5

Table 3 Diagnostic accuracy of cut-off values of CAPAP in serum and urine and urinary TAP to distinguish severe acute pancreatitis from the mild form of the disease

Proenzyme, cut-off valuewithin 24 h of admission	Pre-testprobability%	Sensitivity%	Specificity%	PPV%	NPV%	Positivelikelihoodratio	Post-testprobability%
Amylase serum, >330 U/L	69.4	74	86.4	92.5	59.3	5.4	92.4
Lipase serum, >180 U/L	69.4	84	85.7	93.4	72	5.87	93
CAPAP serum, >1.53 nmol/L	69.4	85	90.9	95.2	74	9.3	95
CAPAP urine, >2.32 nmol/L	69.4	66.7	95.5	96.9	56.7	14.6	97
TAP urine, >10.01 nmol/L	69.4	68.8	40	73.3	34.7	1.13	71.9
Trypsinogen-2 urine, positive	69.4	68	86.4	91.9	54.3	5	91.9

PPV, positive predictive value; NPV, negative predictive value.