Radiation therapy for portal venous invasion by hepatocellular carcinoma

Table 1 List of size of intrahepatic tumor

Size of intrahepatic tumor (cm)	No. of patients
No HCC	1
1-1.99	2
2-2.99	21
3-3.99	11
4-4.99	7
5-5.99	3
6-6.99	2
≥7	5

Table 2 Univariate analysis

	Hazard ratio	95%CI	P value
Child classification (A)	0.217	0.048-0.978	0.0015
No. of HCC ( ≤5)	0.411	0.204-0.828	0.0129
Tumor type (diffuse)	2.897	1.147-7.313	0.0244
No TAE after RT	2.406	1.001-5.786	0.0498
Initial effect (CR)	0.194	0.043-0.878	0.0625
No surgery before RT	0.6	0.247-1.456	0.2589
No PTA before RT	1.373	0.741-2.544	0.3136
No TAE before RT	0.718	0.358-1.438	0.3494
No PTA after RT	1.372	0.654-2.880	0.4026
KPS (<90)	1.252	0.483-0.262	0.6457
age	1.008	0.971-1.046	0.681
Main trunk invasion	1.049	0.573-1.920	0.8772

CR: complete regression; PR: partial regression; SD: stable disease; PD: progressive disease; TAE: transcatheter arterial embolization; RT: radiation therapy; HCC: hepatocellular carcinoma; PTA: percutaneous tumor ablation; CI: confidence interval.

Table 3 Multivariate analysis

	Hazard ratio	95%CI	P value
No. of HCC ( ≤5)	0.414	0.188-0.912	0.0285
No TAE after RT	3.206	1.463-7.024	0.0364
Child classification A	0.729	0.111-4.667	0.0864
Initial effect (CR)	0.314	0.059-1.664	0.5783
Tumor type (diffuse)	1.309	0.190-9.011	0.7019

CR: complete regression; PR: partial regression; SD: stable disease; PD: progressive disease; TAE: transcatheter arterial embolization; RT: radiation therapy; HCC: hepatocellular carcinoma; CI: confidence interval.