Anti-Saccharomyces cerevisiae antibody titers are stable over time in Crohn’s patients and are not inducible in murine models of colitis

Table 1 Baseline characteristics of the study populations tested for anti-Saccharomyces cerevisiae IgG and IgA antibodies. Unless otherwise indicated values are numbers of patients (%)

Study population	Crohn’s disease (n = 66)	Ulcerative colitis (n = 29)	Healthy controls (n = 18)	IBS patients (n = 10)
Age, yr
Mean±SD	38±16	37±15	40±13	57±13
Range	14-82	16-78	17-74	41-81
Male sex	32 (48)	15 (52)	10 (56)	6 (60)
Disease location
Colonic	58 (88)	29 (100)
Ileal	45 (68)
Upper gastrointestinal involvement	3 (5)
Presence of fistulae	15 (23)	1 (3)
Extraintestinal manifestations	4 (6)	0 (0)
Medical therapy
Azathioprine	22 (33)	9 (31)
Infliximab	5 (8)	3 (10)
5-ASA compounds	4 (6)	11 (38)
Methotrexate	4 (6)	0 (0)
Oral steroids	29 (44)	15 (52)
None of the above	19 (29)	7 (24)

Table 2 Mean, standard deviation (SD) and the 95% confidence interval of the mean of the change in ASCA IgG and IgA titers

	∆IgG		∆IgA
	Mean	SD	95%CI	Mean	SD	95%CI
CD	0.01	0.56	(-0.20, 0.22)	-0.04	0.25	(-0.13, 0.05)
UC	0.05	0.15	(-0.03, 0.14)	0.16	0.24	(0.02, 0.29)
IBS	0.05	0.08	(-0.003, 0.09)	-0.01	0.12	(-0.08, 0.06)

Table 3 Effect of the CD clinical characteristics on the following parameters: ASCA IgG and IgA positivity and change in IgG and IgA ASCA titers. Results are expressed as P-values of the mean-difference tests or as correlation coefficients (c)

Clinical characteristics	ASCA IgG	ASCA IgA	∆IgG	∆IgA
Correlation with age	c = –0.140	c = 0.198	c = –0.340	c = –0.197
Male vs female	0.881	0.881	0.089	0.571
Disease Location
Colonic vs non-colonic	0.667	0.169	0.203	0.289
Ileal vs non-ileal	0.285	0.285	0.032a	0.395
Fistular vs Non-fistular disease	0.152	0.075	0.499	0.907
Medical therapy
Azathioprine	0.881	0.881	0.749	0.375
Infliximab	0.233	0.233	0.87	0.844
5-ASA compounds	0.806	0.233	0.903	0.491
Oral steroids	0.512	0.385	0.475	0.531
None of the above medical
therapy vs medical therapy	0.285	0.577	0.438	0.117

^aP<0.05.