Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model

Table 1 Effect of 5-FC treatment on subcutaneous MH tumor growth

		Suicide gene
		None (control)	SuperCD
Treatment	5-FC	1.4 g	n.d.
		3.2 g	n.d.
		1.8 g	n.d.
	Saline (control)	2.5 g	1.8 g
		2.9 g	1.9 g
		3.7 g	2.7 g

Six animals received two sc tumor cell injections (1×10⁷ cells in 70 µL PBS/animal). On d 11, tumor-bearing rats were randomized into two groups and treatment started with twice daily ip injections of 5-FC (283 mg/kg body weight) or saline (control). At the end of 5-FC treatment (d 18), animals were killed, tumors were harvested and weighed. Complete regression of tumors was observed only in the 5-FC-treated SuperCD tumors (n.d.: no detectable tumors).