Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer

Table 1 Clinical data of subjects studied

	HV	GU	EGC	AGC
	(n = 32)	(n = 11)	(n = 13)	(n = 7)
Age (yr)	51 (35-65)	55.5 (24-80)	73.5 (61-87)	65 (48-75)
Gender (M:F)	17:15	5:6	11:2	3:4
Size (cm)	-	1.4 (0.8-2.0)	1.55 (0.8-3.5)	7.7 (4.3-whole stomach)
Invasive	-	-	Tis:T1=11:2	T2:T3:unknown= 3:2:2
Depth

HV: healthy volunteers, GU: Gastric ulcers, EGC: early gastric cancers, AGC: advanced gastric cancers. Tis = mucosa, T1 = submucosa, T2 = proper muscle and subserosa, T3 = serosa.

Table 2 Cut-off points and diagnostic values of sucrose test at each time point for detection of gastric disease (gastric ulcer and gastric cancer)

Time (min)	Urine	15	30	45	60	75	90
Cut-off points1	95	7.4	10.2		11.8	15.2	16.8
Sensitivity (%)	90.3	80.6	83.9	93.5	96.8	96.8	96.8
Specificity (%)	93.8	87.5	93.8	90.6	93.8	96.9	93.8
Accuracy (%)		92.1	84.1	88.9	92.1	95.2	96.8

¹ Cut-off points: Urine as mg/5 h, Serum as μmol/L

Table 3 Sucrose concentrations at 60 min of the 4 groups

	HV	GU	EGC	AGC
Mean (μmol/L)	7.6	26.9	34.4	71.8
SE (μmol/L)	0.7	2.4	5	15.6

Table 4 Sensitivity of sucrose permeability test for each gastric disease

Time (min)	Urine	15	30	45	60	75	90	120
Cut-off points1	95	7.4	10.2	11.8	15.2	16.8	16	14
GU	100	72.7	81.8	100	100	100	100	100
EGC	84.6	76.9	76.9	84.6	92.3	92.3	92.3	92.3
AGC	100	100	100	100	100		100	100

¹Cut-off points: Urine, as mg/5 h; serum, as μmol/L