Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: Its prognostic significance

Table 1 Relationship between serum CD4 value and clinic-opathological features (mean±SD), n (%)

	Group H-CD4	Group L-CD4	P
Variables	(n = 68)	(n = 66)
Gender
Male	57 (83.8)	61 (92.4)	0.205
Female	11 (16.2)	5 (7.6)
Age	60.9±8.8	64.1+9.6	0.046
Location of tumor
Upper	12 (17.6)	11 (16.7)	0.845
Middle	38 (55.9)	40 (60.6)
Lower	18 (26.5)	15 (22.7)
Degree of differentiation
Well	4 (5.9)	6 (9.1)	0.620
Moderately	57 (83.8)	51 (77.3)
Poorly	7 (10.3)	9 (13.6)
Tumor size (cm)	5.3+2.7	5.4+2.5	0.970
Depth of tumor
Tis	2 (2.9)	2 (3.0)	0.051
T1a	6 (8.8)	5 (7.6)
T1b	15 (22.1)	9 (13.6)
T2	14 (20.6)	9 (13.6)
T3	15 (22.1)	33 (50.0)
T4	16 (23.5)	8 (12.2)
Lymph nodes metastasis
Positive	24 (35.3)	31 (53.0)	0.231
Negative	44 (64.7)	35 (47.0)
Lymphatic invasion
Positive	12 (17.6)	18 (27.3)	0.259
Negative	56 (82.4)	48 (72.7)
Venous invasion
Positive	5 (7.4)	11 (16.7)	0.163
Negative	63 (92.6)	55 (83.3)
TNM stage
0	2 (2.9)	2 (3.0)	0.749
I	17 (25.0)	11 (16.7)
IIA	16 (23.5)	18 (27.3)
IIB	10 (14.7)	8 (12.2)
III	23 (33.8)	27 (40.8)
Curability
Curative resection	52 (76.5)	56 (84.8)	0.314
Non curative resection	16 (23.5)	10 (15.2)

Well = well differentiated squamous cell carcinoma; Moderately = moderately differentiated squamous cell carcinoma; Poorly = poorly differentiated squamous cell carcinoma.

Table 2 Relationship between serum CD8 value and clinico-pathological features (mean±SD), n (%)

	Group H-CD8	Group L-CD8	P
Variables	(n = 64)	(n = 70)
Gender
Male	58 (90.6)	60 (85.7)	0.543
Female	6 (9.4)	10 (14.3)
Age	63.4+9.6	61.6+9.1	0.265
Location of tumor
Upper	9 (14.1)	14 (20.0)	0.635
Middle	38 (59.4)	40 (57.1)
Lower	17 (26.5)	16 (22.9)
Degree of differentiation
Well	4 (6.3)	6 (8.6)	0.810
Moderately	53 (82.8)	55 (78.6)
Poorly	7 (10.9)	9 (12.8)
Tumor size (cm)	5.4+2.4	5.3+2.8	0.930
Depth of tumor
Tis	2 (3.1)	2 (2.8)	0.899
T1a	4 (6.3)	7 (10.0)
T1b	11 (17.2)	13 (18.6)
T2	10 (15.6)	13 (18.6)
T3	26 (40.6)	22 (31.4)
T4	11 (17.2)	13 (18.6)
Lymph nodes metastasis
Positive	29 (45.3)	26 (37.1)	0.382
Negative	35 (54.7)	44 (62.9)
Lymphatic invasion
Positive	11 (17.2)	19 (27.1)	0.241
Negative	53 (82.8)	51 (72.9)
Venous invasion
Positive	9 (14.1)	7 (10.0)	0.647
Negative	55 (85.9)	63 (90.0)
TNM stage
0	2 (3.1)	2 (2.8)	0.858
I	12 (18.8)	16 (22.9)
IIA	15 (23.4)	19 (27.1)
IIB	8 (12.5)	10 (14.3)
III	27 (42.2)	23 (32.9)
Curability
Curative resection	51 (79.7)	57 (81.4)	0.830
Non curative resection	13 (20.3)	13 (18.6)

Well = well differentiated squamous cell carcinoma; Moderately = moderately differentiated squamous cell carcinoma; Poorly = poorly differentiated squamous cell carcinoma.

Table 3 Relationship between serum CD4/CD8 ratio and clinico-pathological features (mean±SD), n (%)

	Group H-CD4/8	Group L-CD4/8	P
Variables	(n = 48)	(n = 86)
Gender
Male	38 (79.2)	80 (93.0)	0.036
Female	10 (20.8)	6 (7.0)
Age	61.4+8.9	63.0+9.6	0.322
Location of tumor
Upper	10 (20.8)	13 (15.1)	0.675
Middle	26 (54.2)	52 (60.5)
Lower	12 (25.0)	21 (24.4)
Degree of differentiation
Well	5 (10.4)	5 (5.8)	0.459
Moderately	36 (75.0)	72 (83.7)
Poorly	7 (14.6)	9 (10.5)
Tumor size (cm)	4.9+2.5	5.6+2.7	0.125
Depth of tumor
Tis	2 (4.2)	2 (2.3)	0.213
T1a	4 (8.3)	7 (8.1)
T1b	11 (22.9)	13 (15.1)
T2	8 (16.7)	15 (17.5)
T3	11 (22.9)	37 (43.0)
T4	12 (25.0)	12 (14.0)
Lymph nodes metastasis
Positive	16 (33.3)	39 (34.9)	0.241
Negative	32 (66.7)	47 (65.1)
Lymphatic invasion
Positive	12 (25.0)	18 (20.9)	0.745
Negative	36 (75.0)	68 (79.1)
Venous invasion
Positive	5 (10.4)	11 (12.8)	0.647
Negative	43 (89.6)	75 (87.2)
TNM stage
0	2 (4.2)	2 (2.3)	0.858
I	13 (27.1)	15 (17.5)
IIA	11 (22.9)	23 (26.7)
IIB	6 (12.5)	12 (14.0)
III	16 (33.3)	34 (39.5)
Curability
Curative resection	36 (75.0)	72 (83.7)	0.830
Non curative resection	12 (25.0)	14 (16.3)

Well = well differentiated squamous cell carcinoma; Moderately = moderately differentiated squamous cell carcinoma; Poorly = poorly differentiated squamous cell carcinoma.