No relationship between IL-1B gene polymorphism and gastric acid secretion in younger healthy volunteers

Table 1 Relationship between IL-1B-511 genotypes and H pylori status

Loci	Genotype	H pylori+	H pylori–	Total
		(n=96)	(n=159)	(n=255)
IL-1B-511	C/C	34	63	97
	C/T	46	75	121
	T/T	16	211	37 (14.1%)
IL-1B-31	C/C	72	120	192
	C/T	22	37	59
	T/T	2	22	4 (1.6%)

¹H pylori+ vs H pylori–: x²=0.6; ²H pylori+ vs H pylori–: x²=0.3

Table 2 Common characteristics of 117 subjects (n, mean±SD)

	IL-1B-511 genotype (n =117)
	T/T (n =37)	C/T (n =40)	C/C (n =40)
H pylori+	14	15	181
Sex (F/M)	16/21	18/22	19/212
Age (yr)	21.9±1.5	22.1±1.6	22.3±1.63

¹x²=0.6;

²x²=0.1,

³F=1.4

Table 3 PG I and I/II ratio in different genotypes with or without Helicobacter pylori (H pylori) infection (mean±SD)

		IL-1B-511 genotype
		C/C (n = 97)	C/T (n = 121)	T/T (n = 37)
H pylori+	PGI	38.5 ± 6.7	40.3 ± 7.2	38.0 ± 6.7
(n=96)	PGI/II	4.9 ± 0.4	5.0 ± 0.4	4.7 ± 0.31
H pylori–	PGI	23.6 ± 4.3	24.0 ± 5.0	23.5 ± 3.5
(n=159)	PGI/II	5.0 ± 0.3	4.9 ± 0.3	4.9 ± 0.4

F = 3.7, P = 0.03 (P_T/_Tvs_C/_T = 0.008, P_T/_Tvs_C/_C = 0.04).