Clinical characteristics and distribution of hepatitis B virus genotypes in Guangxi Zhuang population

Table 1 Distribution of HBV genotypes in 156 cases

Patterns of	A	B	C	D	E	F	CD	CB	BD	Non-A-F
genotype
n	–	9	15	33	–	–	43	16	15	25
Incidence rate (%)	–	5.8	9.6	21.2	–	–	27.6	10.3	9.6	16.0

Table 2 Relationship between different HBV genotypes and YMDD mutations, clinical types of CHB, ALT, and HBV DNA level, HBe system

Genotypes	n	Rate of YMDD	Clinical type of CHB			Clinical test
		mutation (%)	Mild and moderate	SevereCHB (%)	Abnormal rate	HBV DNA >105	HBeAg(+)/HBeAb(–)
			CHB (%)		of ALT (%)	copies/mL (%)
B	9	–	8 (88.9)	1 (11.1)	3 (33.3)	4 (44.4)	7/2
C	15	6 (40.0)	4 (26.7)	11 (73.3)	8 (53.3)	9 (60.0)	10/5
D	33	7 (21.2)	14 (42.4)	19 (57.6)	23 (69.7)	22 (66.7)	23/10
CD	43	15 (34.9)	19 (44.2)	24 (55.8)	32 (74.4)	30 (69.8)	28/15
CB	16	6 (37.5)	9 (56.3)	7 (43.7)	9 (56.3)	10 (62.5)	12/4
BD	15	4 (26.7)	7 (46.7)	8 (53.3)	8 (53.3)	9 (60.0)	9/6
Non-A–F	25	8 (32.0)	15 (60.0)	10 (40.0)	12 (48.0)	10 (40.0)	8/17
χ2		2.788	11.272		9.858	7.448	12.841
P		>0.05	>0.05		>0.05	>0.05	<0.05

Table 3 Curative effect after 48 weeks of LAM treatment

Group	n	Recovery rate	HBV DNA level	HbeAg negative	HBeAg/HBeAb
		of ALT (%)	<103 copies/mL (%)	conversion rate (%)
Single genotypes	30	23 (76.7)	24 (80.0)	16 (53.3)	11 (36.7)
Mixed genotypes	35	28 (80.0)	29 (82.9)	18 (51.4)	12 (34.3)
Non-classified genotypes	16	13 (81.3)	14 (87.5)	10 (62.5)	6 (37.5)
χ2		0.168	0.411	0.561	0.065
P		>0.05	>0.05	>0.05	>0.05