Prevalence of gallstone disease in first-degree relatives of patients with cholelithiasis

Table 1 Levels of the most important risk factors for gallstones in cases with or without gallstones

	Cases	Controls	P
	n = 79	n = 79
Male/female (n)	30/49	30/49	NS
Age (yr); mean (CI)	48.6 (45.8–51.4)	48.5 (45.7–51.4)	NS
BMI; mean (CI)	25.5 (24,9–26.4)	25.7 (24.7–26.7)	NS
Number of pregnancies	1.71 (1.29–2.13)	1.47 (1.04–1.89)	NS
(females); mean (CI)

Table 2 Prevalence of GD and levels of the most important risk factors for gallstones in fathers and mothers of subjects with or without gallstones

	Fathers of		Mothers of
	Cases	Controls	Cases	Controls
	n = 31	n = 34	n = 51	n = 51
Age (yr); mean (CI)	70.0 (66.7-73.4)	70.9 (67.6-74.2)	72.4 (69.2-75.5)	71.8 (71.8-74.8)
BMI; mean (CI)	25.7 (24.4-27.0)	27.5 (26.3-28.6)	26.3 (25.1-27.6)	26.3 (25.4-27.3)
Diabetes (%)	3.4a	20.6	20.0	21.2
Number. of pregnancies; mean (CI	-	-	2.9 (2.4-3.4)	2.9 (2.5-3.4)
GD (%)	41.9c	17.6	56.9b	21.6

^aP<0.05 vs controls (χ² = 4.15);

^cP<0.05 vs controls (χ² = 4.66; RR = 1.75 (0.98-2.6 95% CI);

^bP<0.001 vs controls (χ² = 13.32; RR = 2.35 (1.38-4.3 95% CI).

Table 3 Prevalence of GD and levels of the most important risk factors for gallstones in brothers and sisters of subjects with or without gallstones

	Brothers of		Sisters of
	Cases	Controls	Cases	Controls
	n = 50	n = 47	n = 39	n = 44
Age (yr); mean (CI)	48.5 (45.4-51.6)	44.9 (41.4-48.3)	43.9 (39.0-48.8)	48.9 (44.9-52.8)
BMI ; mean (CI)	25.6 (24.6-26.5)	25.5 (24.4-26.6)	24.8 (23.4-26.1)	25.8 (24.5-27.1)
Diabetes (%)	5.9	0	2.7	11.4
No. of pregnancies; mean (CI)	-	-	1.3 (0.9-1.7)	1.5 (1.0-1.9)
GD (%)	10.0	8.5	25.6a	9.1

^aP<0.05 vs controls (χ² = 4.04; RR = 2.03 [0.94-6.22 95%CI])

Table 4 Prevalence of GD and levels of the most important risk factors for gallstones in husbands and wives of subjects with or without gallstones

	Husbands and wives of
	Cases	Controls	P
	n = 63	n = 62
Males/females	40/23	39/23	NS
Age (yr); mean (CI)	50.2 (48.8-51.4)	50.6 (48.9-51.7)	NS
BMI ; mean (CI)	25.9 (24.9-26.6)	26.0 (24.9-27.0)	NS
No. of pregnancies (female);	1.5 (1.0-2.2)	1.6 (0.8-2.1)	NS
mean (CI)
Diabetes (%)	4.8	3.2	NS
GD (%)	9.5	11.2	NS