Acid fibroblast growth factor reduces rat intestinal mucosal damage caused by ischemia-reperfusion insult

Table 1 Effect of aFGF on the apoptotic rates in intestinal villi and crypts after ischemia-reperfusion insult (n = 6, mean±SD, %)

Groups	Villus		Crypt
	R group	A group	R group	A group
C group	37.3 ± 8.6	37.3 ± 8.6	14.4 ± 3.8	14.4 ± 3.8
I group	40.0 ± 6.9	40.0 ± 6.9	13.7 ± 4.1	13.7 ± 4.1
0.25 h after reperfusion	45.3 ± 5.7	35.2 ± 6.7c	15.0 ± 3.2	11.8 ± 2.6
0.5 h after reperfusion	46.3 ± 8.3	37.8 ± 7.4	16.2 ± 4.7	13.0 ± 3.5
1 h after reperfusion	49.5 ± 5.3	45.3 ± 7.4	19.3 ± 5.6	16.2 ± 3.3
2 h after reperfusion	70.2 ± 6.5a	50.5 ± 5.3ac	23.5 ± 6.2a	17.8 ± 4.1c
6 h after reperfusion	76.8 ± 4.7a	49.2 ± 5.0ac	27.2 ± 4.8a	19.3 ± 5.0ac
12 h after reperfusion	84.0 ± 6.2a	52.5 ± 4.6ac	28.0 ± 3.9a	20.5 ± 5.2ac
24 h after reperfusion	41.8 ± 5.4	35.2 ± 5.2	14.2 ± 4.3	9.3 ± 3.6
48 h after reperfusion	33.7 ± 4.8	34.3 ± 6.2	13.3 ± 2.9	11.0 ± 4.3

^aP<0.05 vs C group;

^cP<0.05 vs R group at matched time points.

Table 2 Effect of aFGF on protein expression of PCNA in intestinal villi and crypts after ischemia-reperfusion (n = 6, mean±SD, %)

	Villus		Crypt
Groups	R group	A group	R group	A group
C group	8.5 ± 5.0	8.5 ± 5.0	31.5 ± 5.2	31.5 ± 5.2
I group	8.8 ± 5.3	8.8 ± 5.3	33.3 ± 4.1	33.3 ± 4.1
0.25 h after reperfusion	10.5 ± 5.1	10.7 ± 4.9	39.7 ± 5.4	36.0 ± 5.6
0.5 h after reperfusion	11.5 ± 3.8	14.7 ± 4.3	41.0 ± 4.7a	43.8 ± 5.2a
1 h after reperfusion	12.3 ± 6.2	11.3 ± 5.4	44.3 ± 4.6a	51.5 ± 6.0a
2 h after reperfusion	16.7 ± 4.5a	23.3 ± 5.1ac	48.2 ± 5.3a	67.8 ± 5.3ac
6 h after reperfusion	18.2 ± 3.5a	25.0 ± 6.4ac	47.3 ± 5.5a	76.0 ± 3.8ac
12 h after reperfusion	19.0 ± 5.4a	25.3 ± 4.5ac	52.1 ± 5.1a	79.8 ± 5.2ac
24 h after reperfusion	8.7 ± 4.7	11.2 ± 2.3	43.7 ± 5.4	44.8 ± 6.2
48 h after reperfusion	6.7 ± 2.9	9.2 ± 4.0	38.5 ± 6.1	42.7 ± 4.9

^aP<0.05 vs C group;

^cP<0.05 vs R group at matched time points.

Table 3 Effect of aFGF on plasma D-lactate levels after intestinal ischemia-reperfusion (n = 6, mean±SD, μg/mL)

Groups	R group	A group
C group	0.201 ± 0.008	0.201 ± 0.008
I group	0.212 ± 0.011	0.212 ± 0.011
0.25 h after reperfusion	0.247 ± 0.011	0.225 ± 0.016c
0.5 h after reperfusion	0.281 ± 0.036a	0.222 ± 0.020c
1 h after reperfusion	0.285 ± 0.068a	0.233 ± 0.022
2 h after reperfusion	0.283 ± 0.031a	0.232 ± 0.018ac
6 h after reperfusion	0.293 ± 0.033a	0.252 ± 0.014ac
12 h after reperfusion	0.299 ± 0.025a	0.250 ± 0.018ac
24 h after reperfusion	0.228 ± 0.012	0.223 ± 0.015
48 h after reperfusion	0.231 ± 0.004	0.224 ± 0.009

^aP<0.05 vs C group;

^cP<0.05 vs R group at matched time points.