Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease

Table 1 Full genotype data on all subjects

	Normal controls (n = 208)	ALC (n = 239)	Of ALC		Of AEOD
			AC (n = 67)	AEOD (n = 172)	AICP (n = 144)	ALD (n = 28)
Homozygote wildtype	194	232	63	169	141	28
Heterozygote for insertion	12	4	3	1	1	0
Homozygote for insertion	0	1	0	1	1	0
Heterozygote for deletion	2	2	1	1	1	0

ALC, ICD 10.1/10.2; AC, alcoholic controls; AEOD, alcohol-related end-organ disease; AICP, alcohol induced chronic pancreatitis; ALD, alcoholic liver disease.

Table 2 Normal control and alcoholic figures and comparisons

	Normal controls n = 208 (%)	ALC n = 239 (%)	Fisher’s exact test
Presence of
insertion polymorphism	12 (5.8)	5 (2.1)	P = 0.049 (χ2 = 4.110, P = 0.043)
Genotype for
insertion polymorphism
Heterozygote	12 (5.8)	4 (1.7)	P = 0.030
Homozygote	0 (0.0)	1 (0.4)

ALC, ICD 10.1/10.2.

Table 3 Alcoholic subgroup figures and analyses

	Normal controls n = 208 (%)	Alcoholic controls n = 67 (%)	Alcoholic end organ disease n = 172 (%)	Fisher’s exact test
Presence of
insertion polymorphism	12 (5.8)	3 (4.5)	2 (1.2)	P = 0.045
Genotype for
insertion polymorphism
Heterozygote	12 (5.8)	3 (4.5)	1 (0.6)	P = 0.011
Homozygote	0 (0.0)	0 (0.0)	1 (0.6)