Protective effect of selenium-enriched lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms

Table 1 Changes of AST and ALT activities in mice with hepatic injury after Se-enriched lactobacillus treatment (mean±SE)

Index	Group	Post-injection with CCl4
		1 wk	2 wk
AST (U/mg tissue)	Normal	20.43 ± 0.54a	17.68 ± 1.21a
	Model	28.05 ± 1.03c	26.81 ± 0.46c
	L-Se	23.60 ± 0.93a	17.86 ± 1.75a
	H-Se	18.90 ± 0.94a	18.90 ± 2.26a
ALT (U/mg tissue)	Normal	31.64 ± 0.23	42.93 ± 0.42a
	Model	31.15 ± 0.32	50.61 ± 1.05c
	L-Se	30.71 ± 0.39	49.47 ± 0.26c
	H-Se	28.99 ± 0.13ac	43.64 ± 1.61a

^aP<0.05 vs model group;

^cP<0.05 vs normal group.

Table 2 Changes of GSH-Px and SOD activities in mice with hepatic injury after Se-enriched lactobacillus treatment (mean±E)

Index	Group	Post-injection with CCl4
		1 wk	2 wk
GSH-Px (U/mg tissue)	Normal	6.43 ± 0.67	6.40 ± 0.38a
	Model	6.24 ± 0.36	5.21 ± 0.24c
	L-Se	7.68 ± 0.33	5.67 ± 0.25
	H-Se	8.10 ± 0.21a	6.45 ± 0.31a
SOD (U/mg tissue)	Normal	60.57 ± 2.25a	61.34 ± 0.83a
	Model	47.88 ± 2.15c	48.95 ± 1.19c
	L-Se	54.43 ± 2.43	52.70 ± 2.14c
	H-Se	52.61 ± 3.46	51.50 ± 2.20c

^aP<0.05 vs model group;

^cP<0.05 vs normal group.

Table 3 Changes of phagocytic function in mice with hepatic injury after Se-enriched lactobacillus treatment (mean±SE)

Index	Group	Post-injection with CCl4
		1 wk	2 wk
Phagocytic rate (%)	Normal	17.25 ± 0.81a	15.25 ± 1.18a
	Model	11.67 ± 1.00c	10.64 ± 0.56c
	L-Se	14.92 ± 0.33ac	12.67 ± 0.49a
	H-Se	14.92 ± 0.33ac	12.67 ± 0.49a
Phagocytic index (RBC/macrophage)	Normal	1.75 ± 0.11	1.69 ± 0.08a
	Model	1.46 ± 0.08	1.17 ± 0.06c
	L-Se	1.52 ± 0.12	1.36 ± 0.07
	H-Se	1.72 ± 0.04a	1.55 ± 0.09a

^aP<0.05 vs model group;

^cP<0.05 vs normal group.