Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas

Table 1 Other malignacies in patients with IPMN

	Previous	At diagnosis	Post diagnosis	Total
Gastric cancer	4	7	1	12
Colonic cancer	4	3	0	7
Esophageal cancer	3	1	0	4
Pulmonary cancer	0	2	2	4
Pancreatic cancer	0	2	1	3
Breast cancer	2	0	0	2
Hepatocellular cancer	0	2	0	2
Uterine cancer	1	0	0	1
Pharyngeal cancer	1	0	0	1
Bile duct cancer	0	1	0	1
Prostatic cancer	0	1	0	1
Laryngeal cancer	0	0	1	1
Malignant lymphoma	0	0	1	1

Table 2 Other malignancies of more than two organs in patients with IPMN

Case	Age (yr)	Sex	Previous	At diagnosis	Postdiagnosis
1	76	M	Gastric cancer (EMR, 1 yr ago)		Pulmonary cancer (4 yr after)
			Esophageal cancer (EMR, 1 yr ago)
2	74	F	Uterine cancer (ope, 10 yr ago)	Hepatocellular cancer
				Colonic cancer
3	70	M		Gastric cancer
				Colonic cancer
				Pulmonary cancer
4	83	F		Esophageal cancer	Malignant lymphoma (1 yr after)
5	78	M		Hepatocellular cancer	Gastric cancer (6 yr after)
6	78	M	Esophageal cancer (EMR, 1 yr ago)		Laryngeal cancer (6 yr after)
7	68	M	Esophageal cancer (EMR, 2 yr ago)		Pancreatic cancer (3 yr after)

EMR: endoscopic mucosal resection.

Table 3 Clinicopathological findings of IPMN patients with and with-out other malignancies

	With other malignancies (n = 28)	Without other malignancies (n = 51)	P
Age (yr)	71.9±8.2	66.8±9.3	P<0.05
Male/Female	8/20	34/17	NS
Follow-up period1	3.2±0.5	3.4±0.5	NS
Site of IPMN			NS
Main duct	13	17
Branch duct	15	34
Resection/Nonresection of IPMN	7/20	16/35	NS
Cause of death
Invasive IPMN	1	4
Gastric cancer	4	0
Pulmonary cancer	3	0
Pancreatic cancer	2	0
Colonic cancer	2	0
Esophageal cancer	1	0
Hepatocellular cancer	1	0
Malignant lymphoma	1	0
Pneumonia	1	1
Renal failure	0	1

Table 4 IPMN concomitant with independent pancreatic cancer

Case	Age (yr)	Sex	Syn/Met	Othermalignancies	IPMNlocation	Site	Therapy	Pancreaticlocation	Cancertherapy	Stage	Prognosis
1	71	M	Syn	None	Head	Branch	None	Body	DP	III	Died 7 mo after operation
2	75	M	Syn	None	Head	Branch	None	Head	None	IV	Died 8 mo after diagnosis
31	68	M	Met	Esophageal cancer	Head	Branch	PD	Head	PD	II	Alive now 3 yr after diagnosis of IPMN

Syn: synchronous, Met: metachronous, PD: pancreatoduodenectomy, DP: distal pancreatectomy. ¹: This case is the same as case 7 in Table 2.