Local recurrence is an important prognostic factor of hepatocellular carcinoma

Table 1 Characteristics of 140 patients at base line (mean±SD)

		(Range)
Age (yr)	63.3 ± 8.54	(35-83)
Male/female	95/45
Child (A/B/C)	77/48/15
Albumin (g/dL)	3.56 ± 0.43	(2.5-4.5)
Bilirubin (mg/dL)	1.19 ± 0.99	(0.4-10.3)
Platelet (104/L)	9.74 ± 6.0	(0.8-69.9)
ALT (U/L)	84.58 ± 47.04	(14-266)
HPT (%)	60.98 ± 17.14	(25-116)
ICG-R15 (%)	28.13 ± 15.29	(3.5-76.5)
AFP (ng/mL)	155.37 ± 565.3	(2-5 653)
Tumor size (mm)	20.51 ± 8.26
Tumor number	1.51 ± 0.79

Table 2 Comparison of clinical backgrounds between local recurrence group and local recurrence-free group

	Local recurrence
	(+)	(-)
n	44	96
Albumin (g/dL)	3.47 ± 0.49	3.60 ± 0.40
Bilirubin (mg/dL)	1.15 ± 0.53	1.20 ± 1.15
Platelets (104/L)	10.01 ± 9.89	9.62 ± 4.37
ALT (U/L)	85.16 ± 41.76	84.31 ± 49.50
HPT (%)	62.28 ± 18.64	60.35 ± 16.44
ICG-R15 (%)	29.04 ± 15.23	27.72 ± 15.39
AFP (ng/mL)	153.83 ± 539.31	63.24 ± 118.58
Tumor size (mm)	24.00 ± 9.48	18.92 ± 7.15d
Tumor number	1.77 ± 0.94	1.39 ± 0.69b
TACE prior to PEIT	22 (50%)	59 (61%)

^bP<0.01 vs local recurrence (+);

^dP<0.001 vs local recurrence (+).

Table 3 Comparison of features of recurrence after initial treatment for HCC between local recurrence group and local recurrence-free group

	Local recurrence
	(+)	(-)
Recurrent tumor number	3.6 ± 0.61	2.3 ± 1.9d
Recurrent tumor size	33.0 ± 22.02	19.4 ± 8.8d
Recurrence-free period	325.6 ± 216.8	710.5 ± 813.3b
Treatment for recurrence
PEIT (+/-)	25/16	65/16
TACE (+/-)	21/20	24/57

¹Including both local and distant recurred tumors;

²calculated from the size of locally recurred tumors;

^bP<0.01 vs local recurrence (+),

^dP<0.001 vs local recurrence (+).

Table 4 Univariate analysis of prognostic factors for HCC

Variables		n	P	Exp	95%CI
Albumin (g/dL)	>3.5	74	0.0455	1.694	1.011 - 2.841
	≤3.5	60
Bilirubin (mg/dL)	<1.0	62	0.4059	1.246	0.742 - 2.091
	≥1	70
Platelet (104/L)	>8.0	79	0.8301	1.057	0.637 - 1.753
	≤8	60
ALT (U/L)	<75	65	0.2317	1.373	0.817 - 2.310
	≥75	74
HPT (%)	>55	76	0.1665	0.688	0.406 - 1.168
	≤55	59
ICG-R15 (%)	<30	67	0.0003	2.905	1.637 - 5.156
	≥30	45
AFP (ng/mL)	<30	59	0.0269	1.879	1.075 - 3.287
	≥30	56
Tumor size (mm)	<20	73	0.0174	1.882	1.117 - 3.170
	≥20	67
Tumor number	1	91	0.017	1.863	1.117 - 3.106
	≥2	49
Local recurrence	(+)	45	0.0003	2.579	1.540 - 4.317
	(-)	95
Distant recurrence	(+)	111	0.225	1.63	0.740 - 3.951
	(-)	29
TACE	(+)	81	0.5885	1.156	0.683 - 1.958
	(-)	59

Table 5 Multivariate analysis of prognostic factors for HCC

Variables	P	Exp	95%CI
Albumin	0.2424	1.49	0.764 - 2.906
ICG-R15 (%)	0.0074	2.498	1.278 - 4.882
AFP (ng/mL)	0.1816	1.557	0.813 - 2.983
Tumor size (mm)	0.0124	2.267	1.193 - 4.308
Tumor number	0.0469	1.845	1.008 - 3.375
Local recurrence	0.0081	2.362	1.250 - 4.462