Metastatic bone cancer as a recurrence of early gastric cancer - characteristics and possible mechanisms

Table 1 Clinicopathological features of early gastric cancer cases giving rise to bone metastasis in Japan

Age (range)		56.6 (33-78)
(n = 37)
Sex	Male	18
(n = 43)	Female	25
Location	Upper third	4
(n = 28)	Middle third	13
	Lower third	7
	Whole stomach	4
Depth	Mucosa	18
(n = 35)	Submucosa	17
Timing	Synchronous	14
(n = 40)	Recurrence	26
Diagnosis	Plain bone X-ray	8
(n = 24)	Bone scintigraphy	13
	Autopsy	1
	Fracture	1
	Bone marrow aspiration	1
Macroscopic type1	IIa	2
(n = 36)	IIb	6
	IIc	21
	IIc+III	5
	IIa+IIc	1
	IIb+IIc	1
Histological type2	Tub	9
(n = 48)	Por	14
	Sig	23
	Ud	2
Lymph node metastasis3	n0	13
(n = 29)	n1	5
	n2	4
	n3	3
	n4	4

¹IIa: elevated type, IIb: flat type, IIc: depressed type, III: excavated type,

²tub: tubular adenocarcinoma, por: poorly differentiated adenocarcinoma, sig: signet-ring cell carcinoma, ud: undifferentiated carcinoma, and include cases with multiple lesions.

³The General Rules for the Gastric Cancer Study (The 12^th Edition), Japanese Research Society for Gastric Cancer.

Table 2 Distant metastatic sites other than lymph node of early gastric cancer with bone metastasis (n = 16, nine cases that had more than two distant metastasis are included)

Lung	11
Liver	4
Brain	2
Kidney	2
Pleura	2
Ovary	2
Meninx	2
Spleen	2
Thyroid	1
Peritoneum	1
Diaphragm	1