Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver

doi:10.3748/wjg.v11.i35.5512

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Sep 21, 2005 (publication date) through Nov 12, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Sep 21, 2005; 11(35): 5512-5516
Published online Sep 21, 2005. doi: 10.3748/wjg.v11.i35.5512

Table 1 Composition of experimental diets (g/L)

Ingredients	Control	Ethanol
Casein	41.4	41.4
DL-Methionine	0.3	0.3
L-Cystine	0.5	0.5
Cellulose	10	10
Maltose dextrin	115.2	25.6
Corn oil	8.5	8.5
Olive oil	28.4	28.4
Safflower oil	2.7	2.7
Mineral mix¹	8.75	8.75
Vitamin mix²	2.5	2.5
Choline bitartrate	0.53	0.53
Xanthan gum	3	3
Ethanol	–	45.5

¹AIN-76 mineral mix provided the following g/kg mix: calcium phosphate, dibasic, 500; sodium chloride, 74; potassium citrate·H₂O, 220; potassium sulfate, 52; magnesium oxide, 24; manganous carbonate, 3.5; ferric citrate, 6; zinc carbonate, 1.6; cupric carbonate, 0.3; potassium iodate, 0.01; sodium selenite, 0.01; chromium K sulfate.12H2O, 0.55; sucrose, finely powdered, 118.03; Dyets, Bethlehem, PA, USA.

²AIN-76A vitamin mix provided the following g/kg mix: thiamine HCl, 0.6; riboflavin, 0.6; pyridoxine HCl, 0.7; niacin, 3; calcium pantothenate, 1.6; folic acid, 0.2; biotin, 0.02; vitamin B12 (0.1%), 1; vitamin A palmitate (500 000 IU/g), 0.8; vitamin D3 (400 000 IU/g), 0.25; vitamin E acetate (500 IU/g), 10; menadione sodium bisulfite, 0.08; sucrose, finely powdered, 981.15; Dyets, Bethlehem, PA, USA.

Table 2 Effect of TCM on body weight and liver weight of rats fed experimental diets for 10 wk and treated with TCM for the last 4 wk

Wk	Group	Body weight (g)	Liver/body weight (g/BW 100 g)
0	–	134.8±5.6	4.03±0.33
6	CD	306.6±14.2	2.69±0.22
	ED	265.4±13.5^b	3.14±0.11^b
8	CD	309.4±16.3^a^c	2.74±0.22^e
	ED	293.2±17.2^c	3.20±0.26^a
	TCM2000	315.0±15.2^a	2.97±0.14^c
	TCM667	299.2±20.9^a^c	2.90±0.25^c^e
	TCM222	294.0±15.1^c	2.93±0.18^c^e
10	CD	350.8±19.7^a	2.55±0.13^e
	ED	308.0±12.7^c^e	2.99±0.31^a
	TCM2000	317.8±15.6^c	2.80±0.08^a^c
	TCM667	319.0±17.8^c	2.74±0.21^c^e
	TCM222	299.4±20.1^e	2.84±0.17^a^c

^aP<0.05,

^cP<0.05,

^eP<0.05, vs others,

^bP<0.001 vs control.

Table 3 Effect of TCM on serum LDL-C, VLDL-C and HDL-C concentration of rats fed experimental diets for 10 wk and treated with TCM for the last 4 wk

Wk	Group	LDL-C	VLDL-C mg/dL	HDL-C
0		16.66±9.58	7.41±1.87	31.20±9.73
6	CD	26.46±13.45	8.62±3.67	35.21±6.98
	ED	41.39±17.36^b	22.33±1.33^d	28.65±7.68^b
8	CD	20.21±9.15^e	8.72±4.21^e	48.36±4.47^a
	ED	49.53±17.02^a	25.90±2.88^a	24.94±7.93^e
	TCM2000	30.15±4.21^c	16.43±2.23^c	31.70±3.74^c
	TCM667	44.78±10.26^a	8.47±1.71^e	32.94±6.71^c
	TCM222	45.55±9.66^a	10.94±1.88^e	30.67±5.65^c
10	CD	12.02±8.78^g	4.75±0.60^e	55.36±10.48^a
	ED	69.94±11.90^a	18.05±3.30^a	20.42±6.21^e
	TCM2000	26.23±9.99^e	7.78±1.54^c	38.27±9.33^c
	TCM667	35.59±8.91^c	6.59±1.93^c	37.71±6.74^c
	TCM222	39.14±8.47^c	6.95±1.57^c	35.67±3.04^c

^aP<0.05,

^cP<0.05,

^eP<0.05,

^gP<0.05, vs others,

^bP<0.001,

^dP<0.001 vs control.

Table 4 Effect of TCM on serum AST and ALT activities of rats fed experimental diets for 10 wk and treated with TCM for the last 4 wk

Wk	Group	AST (U/mL)	ALT (U/mL)
0		71.79±9.39	32.67±8.52
6	CD	89.72±6.17	28.00±6.63
	ED	133.30±12.78^b	68.96±9.22^b
8	CD	94.85±8.12^c^e	38.45±8.97^c
	ED	119.52±14.73^a	62.60±9.48^a
	TCM2000	86.20±9.89^e	33.92±9.26^c^e
	TCM667	99.21±6.41^c	29.84±9.44^e
	TCM222	103.61±6.92^c	59.37±7.07^a
10	CD	96.97±9.97^a^c	23.50±3.02^e
	ED	105.24±12.06^a	56.74±9.76^a
	TCM2000	86.13±9.71^e	36.23±9.92^c
	TCM667	86.54±9.66^e	27.73±9.87^e
	TCM222	88.34±6.72^c^e	40.80±9.44^c

^aP<0.05,

^cP<0.05,

^eP<0.05, vs others,

^bP<0.001 vs control.

Citation: Kwon HJ, Kim YY, Choung SY. Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver. World J Gastroenterol 2005; 11(35): 5512-5516
URL: https://www.wjgnet.com/1007-9327/full/v11/i35/5512.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i35.5512