Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients

Table 1 COX-2 mRNA expression in gastric tissues

Tissues	COX-2 mRNA expression		%
	+	–
Gastric cancer	20	17	54
Paired adjacent corpus	6	28	18
Paired adjacent antrum	2	33	6
Corpus of first-degree relatives	6	23	21
Antrum of first-degree relatives	13	16	45
Corpus of healthy control	1	17	6
Antrum of healthy control	1	17	6

Table 2 Correlation between COX-2 mRNA expression and H pylori infection

H pylori	COX-2 mRNA expression
	Antrum	%	Corpus	%	Total	%
Positive	12/34	35	8/36	22	20/70	29
Negative	4/44	9	4/39	10	8/83	10
P		<0.005		>0.05		<0.005