There is no association between K469E ICAM-1 gene polymorphism and biliary atresia

Table 1 ICAM-1 genotypic and allele distribution in BA patients and controls

	BA patients, n (%) n = 83	Controls, n (%) n = 115	Odds ratio (95% CI)	P
Age (yr)	6.09±4.67	13.07±2.13	<0.0005
Male	37:46:00	57:58:00	0.49
Genotype
E/E	28 (33.74)	41 (35.65)	0.92 (0.51–1.66)	0.78
E/K	7 (8.43)	11 (9.57)	0.87 (0.32–2.35)	0.78
K/K	48 (57.83)	63 (54.78)	1.13 (0.64–2.00)	0.67
Alleles
E	63 (37.95)	93 (40.43)	0.90 (0.60–1.36)	0.62
K	103 (62.05)	137 (59.57)	1.11 (0.74–1.67)
E/K ratio	0.61	0.68

Table 2 Demographic data, liver function test, and serum sICAM-1 levels between BA patients without jaundice and with persistent jaundice (mean±SD)

BA patients	No jaundice (n = 41)	Persistent jaundice (n = 31)	P
Age (yr)	6.41±4.05	6.00±5.91	0.73
Male:female	22:19	11:20	0.12
Albumin (g/dL)	4.41±0.56	3.71±0.83	<0.0005
Total bilirubin (mg%)	0.79±0.44	12.04±10.53	<0.0005
DB (mg%)	0.24±0.26	9.36±7.85	<0.0005
AST (IU/L)	84.12±67.28	228.26±130.45	<0.0005
ALT (IU/L)	96.93±93.83	161.84±97.93	0.006
AP (IU/L)	380.90±249.80	593.20±293.49	0.002
GGT (IU/L)	163.16±175.49	384.65±404.72	0.004
sICAM-1 (<3 500:≥3 500 ng/mL)	37:04:00	11:20	<0.0005

Table 3 ICAM-1 genotypic and allele distribution in BA patients without jaundice and with persistent jaundice

	No jaundice, n (%) n = 34	Jaundice, n (%) n = 29	Odds ratio (95%CI)	P
Age (yr)	5.91±3.92	5.66±5.17	0.84
Male	18:16	11:18	0.23
Genotype
E/E	9 (26.47)	10 (34.48)	0.68 (0.23-2.01)	0.49
E/K	3 (8.82)	3 (10.34)	0.83 (0.15-4.52)	0.84
K/K	22 (64.71)	16 (55.18)	1.49 (0.52-4.11)	0.44
Alleles
E	21 (30.88)	23 (39.66)	0.68 (0.32-1.42)	0.3
K	47 (69.12)	35 (60.34)	1.47 (0.70-3.07)
E/K ratio	0.45	0.66