ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9

Table 1 Grades of fibrosis in rat liver

Groups	4 wk						6 wk
	0	1	2	3	4	n	0	1	2	3	4	n
Mo	0	1	5	0	1	7	0	0	0	3	3	6
Pea,e	1	3	2	0	0	6	0	1	1	4	0	6
Nca,c	6	0	0	0	0	6	6	0	0	0	0	6

^aP<0.05 vs Mo;

^cP<0.05 vs Pe; ^eP<0.05 Pe (4 wk) vs Pe (6 wk). Mo: model group; Pe: perindopril group; Nc: control group.

Table 2 Effect of perindopril on serum levels of HA and LN (mean±SD)

Groups	n	HA (μg/L)	LN (μg/L)
Nc	7	74.58±10.51	100.29±4.99
Pe (4 wk)	7	81.59±12.60c	101.95±227c
Pe (6 wk)	8	82.07±13.66e	94.84±3.54b
Mo (4 wk)	7	142.41±31.34a	114.99±2.28a
Mo (6 wk)	7	147.86±18.92a	113.72±2.14a

^aP<0.05 vs Nc;

^bP<0.01vs Mo (6 wk);

^cP<0.05 vs Mo (4 wk);

^eP<0.05 vs Mo (6 wk).