Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression

Table 1 Effect of long-term omeprazole therapy on gastric epithelial cell kinetics (mean±SD)

	Omeprazole (n = 14)
Endoscopy (mo)	0	6
Proliferation index (%)	40.9 ± 13.8	54.1 ± 16.6
Apoptosis (%)	45.3 ± 8.7	49.5 ± 10.3
P53 (%)	28.7 ± 4.3	28.9 ± 12.7
EGFR (%)	17.6 ± 11.9	21.9 ± 7.9

Table 2 Effect of long-term esomeprazole therapy on gastric epithelial cell kinetics (mean±SD)

	Esomeprazole (n = 12)
Endoscopy (mo)	0	6
Proliferation index (%)	39.6 ± 8.7	52.8 ± 10.4
Apoptosis (%)	43.5 ± 9.8	48.9 ± 9.8
P53 (%)	29.2 ± 10.7	29.6 ± 11.5
EGFR (%)	16.8 ± 8.1	22.3 ± 8.1