Effects of iron manipulation on trace elements level in a model of colitis in rats

Table 1 Clinical and biochemical aspects of colitis

	Controls	Standard diet (Fe, 200 mg/kg)	Iron-supplemented diet (1 700 mg/kg)	Iron-deprived diet (45 mg/kg)
Colon wet weight (g)	2.2±0.2	4.0±0.9a	3.8±0.8	2.1±0.4c
Macroscopic damage score	0±0	8.75±2.5	7.4±1.4	3.6±1.1c
Myeloperoxidase U/mg	3.5±0.6	19.4±5.2	61.4±7.9b	24.5±7.1

^aP<0.05 vs controls;

^bP<0.01 vs standard diet;

^cP<0.05 vs standard diet.

Table 2 Hepatic and colonic zinc and copper concentrations in controls and colitis

	Zinc mg/g		Copper mg/g
	Hepatic	Colonic	Hepatic	Colonic
Controls	99.8±2.1	133.4±6.1	54.4±1.6	18.6±0.9
Standard diet	140.2±6.2a	113.9±5.8	20.8±0.7d	18.6±0.9
Iron-supplemented diet	92.6±5b	132.2±10.2	44.2±3.9	21±2.1
Iron-deprived diet	117.2±4.4	101.6±5.1	19.7±0.8d	36.2±5.9c

^aP<0.05 vs controls;

^bP<0.01 vs standard diet;

^cP<0.05 vs controls and standard diet;

^dP<0.001 vs controls.