Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation

Table 1 Case number of pre-cirrhotic and post-cirrhotic deaths

Pre-cirrhotic death		Post-cirrhotic death
ANIT OG 25 mg/kg	0	0
ANIT OG 50 mg/kg	0	0
ANIT OG 125 mg/kg	0	3
ANIT IP 25 mg/kg	0	0
ANIT IP 50 mg/kg	0	0
ANIT IP 125 mg/kg	1	0
ANIT modified	0	1
AA OG from 0.2 to 1.0 mmol/kg	0	0
CCl4 OG 0.8 g/kg	0	5
CCl4 OG 1.6 g/kg	2	7
CCl4 OG 2.0 g/kg	5	5
CCl4 IP 0.8 g/kg	4	0
CCl4 IP 1.6 g/kg	6	1
CCl4 IP 2.0 g/kg	2	8
DDC OG 0.25 mg	0	0
DDC OG 0. 5 mg	0	1
DDC OG 2.5 mg	0	3
DDC OG 5 mg	0	4
DDC 0.1% diet	0	3
Silica (SC 3.5 g/kg or IP 1.6 g/kg)	0/0	0/0
CBDL	0	10

OG: Oral gavage; IP: intraperitoneal; SC: subcutaneous.

Table 2 Histopathological changes after inducing liver injuries

	Fatty change	Necrosis/fibrosis	Cirrhosis	Bile lake
ANIT OG 25 mg/kg	0	10	2	0
ANIT OG 50 mg/kg	4	10	4	0
ANIT OG 125 mg/kg	5	10	8	0
ANIT IP 25 mg/kg	0	9	1	0
ANIT IP 50 mg/kg	1	10	1	0
ANIT IP 125 mg/kg	4	10	9	0
ANIT modified	4	10	5	0
AA OG from 0.2 to 1.0 mmol/kg	31	22	0	0
CCl4 OG 0.8 g/kg	4	10	5	0
CCl4 OG 1.6 g/kg	5	10	8	0
CCl4 OG 2.0 g/kg	8	10	5	0
CCl4 IP 0.8 g/kg	3	10	2	0
CCl4 IP 1.6 g/kg	5	10	4	0
CCl4 IP 2.0 g/kg	6	10	8	0
DDC OG 0.25 mg	0	10	3	6
DDC OG 0. 5 mg	0	10	6	9
DDC OG 2.5 mg	0	10	10	10
DDC OG 5 mg	0	10	10	10
DDC 0.1% diet	0	10	10	9
Silica (SC 3.5 g/kg or IP 1.6 g/kg)	0/0	0/0	0/0	0/0
CBDL	0	10	10	10

OG: oral gavage; IP: intraperitoneal; SC: subcutaneous. ¹1 for 0.8 mmol/kg and 2 for 1.0 mmol/kg; ²1 for 0.8 mmol/kg and 1 for 1.0 mmol/kg.