Prognostic value of KIT mutation in gastrointestinal stromal tumors

Table 1 Relationship of C-kit mutation and clinicopathological marker

Clinicalpathological	Total	C-kit		C-kit		χ2	P
		Case	Percent	Case	Percent
Total	82	34		48
Age (yr)
<40	12	5	15	7	15%	0.0002	0.9877
40	70	29	85	41	85%
Sex
Man	56	24	71	32	67%	0.1413	0.7069
Woman	26	10	29	16	33%
Tumor size
1-5.4	46	10	29	36	75%	16.795	< 0.0001
5.5	36	24	71	12	25%
Location of tumors
Esophagus	3	0	0	3	6%
Stomach	42	14	41	28	58%	7.5243	0.0569
Intestine	35	18	53	17	36%
Mesentery	2	2	6	0	0%
Cell type
Spindle	73	29	85	44	92%	0.8272	0.3631
Epithelioid	9	5	15	4	8%
PCNA index
0	19	7	21	12	25%
+	49	15	44	34	71%	17.099	0.0007
++	13	12	35	1	2%
+++	1	0	0	1	2%
Mitotic
<5	67	22	65	45	94%	11.233	0.00008
5/50	15	12	35	3	6%
Hemorrhage
Yes	25	12	35	13	27%	0.6331	0.4262
No	57	22	65	35	73%
Necrosis
Yes	37	20	59	17	35	4.4036	0.0359
No	45	14	41	31	65
Microscopic
Yes	16	15	44	1	2	22.391	< 0.0001
No	66	19	56	47	98
C-kit expression
Positive	80	33	97	47	98	0	1
Negative	2	1	3	1	2

Table 2 Correlation between C-kit mutation and prognostic factors

Prognostic	Total	C-kit mutation-positive subtype		C-kit mutation-negative subtype		χ2	P
		Case	Percent	Case	Percent
Total	82	34	48
Recurrence
Yes	18	13	38	5	10	16.333	0.0001
No	64	21	62	43	90
Metastasis	16	13	38	3	6	12.9649	0.0003
Live	10	9	26	1	2
Abdominal cavity	3	2	6	1	2
Distant	3	2	6	1	2
Prognosis
Survival	63	20	59	43	90	11.6464	0.0006
Death	19	14	41	5	10